2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HFY-4A

HFY-4A is a HDAC inhibitor. HFY-4A inhibits breast cancer cell proliferation, migration, and invasion, and induces cell apoptosis. HFY-4A induces immunogenic cell death (ICD). HFY-4A inhibits tumor growth in breast cancer xenograft mouse models.

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HFY-4A Chemical Structure

HFY-4A Chemical Structure

CAS No. : 2094810-82-7

Size Price Stock Quantity
5 mg USD 230 In-stock
10 mg USD 365 In-stock
25 mg USD 730 In-stock
50 mg USD 1170 In-stock
100 mg USD 1880 In-stock
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Based on 1 publication(s) in Google Scholar

HFY-4A Related Antibodies

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Description

HFY-4A is a HDAC inhibitor. HFY-4A inhibits breast cancer cell proliferation, migration, and invasion, and induces cell apoptosis. HFY-4A induces immunogenic cell death (ICD). HFY-4A inhibits tumor growth in breast cancer xenograft mouse models[1].

Molecular Weight

333.38

Formula

C20H19N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ONC(/C=C/C(C=C1)=CC=C1CNCC(C=C2)=NC3=C2C=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (374.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9996 mL 14.9979 mL 29.9958 mL
5 mM 0.5999 mL 2.9996 mL 5.9992 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9996 mL 14.9979 mL 29.9958 mL 74.9895 mL
5 mM 0.5999 mL 2.9996 mL 5.9992 mL 14.9979 mL
10 mM 0.3000 mL 1.4998 mL 2.9996 mL 7.4990 mL
15 mM 0.2000 mL 0.9999 mL 1.9997 mL 4.9993 mL
20 mM 0.1500 mL 0.7499 mL 1.4998 mL 3.7495 mL
25 mM 0.1200 mL 0.5999 mL 1.1998 mL 2.9996 mL
30 mM 0.1000 mL 0.4999 mL 0.9999 mL 2.4997 mL
40 mM 0.0750 mL 0.3749 mL 0.7499 mL 1.8747 mL
50 mM 0.0600 mL 0.3000 mL 0.5999 mL 1.4998 mL
60 mM 0.0500 mL 0.2500 mL 0.4999 mL 1.2498 mL
80 mM 0.0375 mL 0.1875 mL 0.3749 mL 0.9374 mL
100 mM 0.0300 mL 0.1500 mL 0.3000 mL 0.7499 mL
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HFY-4A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HFY-4A2094810-82-7HDACHistone deacetylasesbreast cancerICDtumorxenograftMCF7T47DInhibitorinhibitorinhibit

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