2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC6-IN-44

HDAC6-IN-44 (compound H10) is a selective HDAC6 inhibitor with an IC50 value of 8.97 nM. HDAC6-IN-44 can inhibit the idiopathic pulmonary fibrosis (IPF) phenotype and exhibits antifibrotic activity. Additionally, HDAC6-IN-44 reduces fibrogenesis in a bleomycin-induced pulmonary fibrosis mouse model and demonstrates good metabolic stability. HDAC6-IN-44 holds promise for research in the field of idiopathic pulmonary fibrosis.

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HDAC6-IN-44 Chemical Structure

HDAC6-IN-44 Chemical Structure

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HDAC6-IN-44 Related Antibodies

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Description

HDAC6-IN-44 (compound H10) is a selective HDAC6 inhibitor with an IC50 value of 8.97 nM. HDAC6-IN-44 can inhibit the idiopathic pulmonary fibrosis (IPF) phenotype and exhibits antifibrotic activity. Additionally, HDAC6-IN-44 reduces fibrogenesis in a bleomycin-induced pulmonary fibrosis mouse model and demonstrates good metabolic stability. HDAC6-IN-44 holds promise for research in the field of idiopathic pulmonary fibrosis[1].
IC50 & Target[1]

HDAC6

8.97 nM (IC50)

In Vitro

HDAC6-IN-44 (compound H10) (2.5-10 μM, 1-300 μM, 48 h) inhibits TGF-β-induced proliferation of HELF cells, cell proliferation and their HDAC6 activity in a dose-dependent manner without causing significant cytotoxic effects[1].
HDAC6-IN-44 interferes with the TGF-β1-related fibrosis process by acting on HDAC6-related signaling pathways[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-44 Related Antibodies

Cell Viability Assay[1]

Cell Line: HELF cells
Concentration: 2.5-10 μM (cell proliferation test), 1-300 μM (survival toxicity test)
Incubation Time: 48 h
Result: Inhibited TGF-β-induced HELF cell proliferation without significantly inhibiting cell survival at a maximum concentration of approximately 10 μM.

Western Blot Analysis[1]

Cell Line: HELF cells
Concentration: 2.5-10 μM
Incubation Time: 48 h
Result: Exhibited dose-dependent increase in acetylated α-tubulin expression and has no effect on histone H3 acetylation, while attenuating the elevated expression of all marker proteins induced by TGF-β1.
In Vivo

HDAC6-IN-44 (compound H10) (0.1 mL/10g, i.p., daily for 3 weeks) significantly inhibits the increase in HDAC6 activity and collagen deposition in lung tissue in a mouse model of pulmonary fibrosis[1].
HDAC6-IN-44 (0.1 mL/10g, i.p., daily for 3 weeks) can inhibit the progression of pulmonary fibrosis in a dose-dependent manner in a mouse model of pulmonary fibrosis[1].
Cell Viability Assay[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bleomycin-induced pulmonary fibrosis mouse model[1]
Dosage: 0.1 mL/10g
Administration: Intraperitoneal injection (i.p.) , daily for 3 weeks
Result: Caused the blue collagen fiber deposition to be spot-like, with the surrounding alveolar cavity slightly collapsed and the alveolar wall thickened, but the collagen fiber deposition was significantly less than that in the model group. Additionally, HDAC6-IN-44 could dose-dependently inhibit the expression of α-SMA and p-Smad2/3 in BLM-induced pulmonary fibrosis in mice.
Molecular Weight

351.40

Formula

C20H21N3O3
SMILES

O=C(NO)C1=CC=C(CN2C([C@@](CCC3)([H])N3CC4=CC=CC=C42)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC6-IN-44 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-44HDACHistone deacetylasesHELF cellsBleomycin-induced pulmonary fibrosis mouse modelIdiopathic pulmonary fibrosisInhibitorinhibitorinhibit

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