2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Guanethidine sesquisulfate

Guanethidine sesquisulfate, an antihypertensive agent, is an adrenergic neurone blocking agent. Guanethidine sesquisulfate enters noradrenergic nerve terminals by the neuronal amine carrier.

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Guanethidine sesquisulfate Chemical Structure

Guanethidine sesquisulfate Chemical Structure

CAS No. : 60-02-6

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Guanethidine sesquisulfate Related Antibodies

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Description

Guanethidine sesquisulfate, an antihypertensive agent, is an adrenergic neurone blocking agent. Guanethidine sesquisulfate enters noradrenergic nerve terminals by the neuronal amine carrier[1][2].

In Vivo

Guanethidine sesquisulfate (5-40 mg/kg; intraperitoneal injection; daily; for 4-28 days; male Wistar rats) treatment for 28 days by 40 mg/kg results in an incomplete sympathectomy accompanied by a partially irreversible hypersensitivity to noradrenaline, whereas 5 mg/kg does not induce histological or permanent haemodynamic changes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (approximately 200 g)[2]
Dosage: 5 mg/kg or 40 mg/kg
Administration: Intraperitoneal injection; daily; for 4, 8, 14, or 28 days
Result: Lowered the blood pressure by 40 mg/kg, the decrease being reversible on discontinuation. The hypersensitivity was partly reversible on discontinuation, but a significantly increased sensitivity of the heart rate to noradrenaline was observed 60 days after discontinuation by 40 mg/kg for 28 days. Histologically a profound loss of nerve cells of the superior cervical ganglion was observed by 40 mg/kg.
Molecular Weight

247.34

Formula

C10H22N4.1/2H2O4S
CAS No.
SMILES

O=S(O)(O)=O.N=C(NCCN1CCCCCCC1)N.[0.5]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Guanethidine sesquisulfate Related Classifications

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Keywords:

Guanethidine sesquisulfate60-02-6Adrenergic ReceptorBeta Receptorantihypertensive agentadrenergic neurone blocking agentInhibitorinhibitorinhibit

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