THAP3 - THAP domain containing 3 Gene

Homo sapiens

Gene ID: 90326 | Gene type: protein coding

About THAP3

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,624,868-6,635,595 (from NCBI)

This gene has 8 transcripts (splice variants), 148 orthologues and 7 paralogues. Ubiquitous expression in kidney (RPKM 8.5), spleen (RPKM 6.2) and 25 other tissues.

Summary

Predicted to enable DNA binding activity and metal ion binding activity. Involved in positive regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Apr 2022]

THAP3 Products(8)

mRNA	Protein	Name
NM_001195752.2	NP_001182681.1	THAP domain-containing protein 3 isoform 1
NM_001195753.2	NP_001182682.1	THAP domain-containing protein 3 isoform 3
NM_001394496.1	NP_001381425.1	THAP domain-containing protein 3 isoform 4
NM_001394497.1	NP_001381426.1	THAP domain-containing protein 3 isoform 5
NM_001394498.1	NP_001381427.1	THAP domain-containing protein 3 isoform 6
NM_001394499.1	NP_001381428.1	THAP domain-containing protein 3 isoform 7
NM_001394500.1	NP_001381429.1	THAP domain-containing protein 3 isoform 8
NM_138350.4	NP_612359.2	THAP domain-containing protein 3 isoform 2

THAP3 Protein Structure

THAP

0
100
200
239 a.a.

Protein Preferred Names

Protein Names

THAP domain-containing protein 3

THAP domain containing, apoptosis associated protein 3

Related Diseases

Diseases

Alias

Brain Malformations With Or Without Urinary Tract Defects

Chromosome 1p32-P31 Deletion Syndrome	Nfia-Related Disorder
Chromosome 1, Monosomy 1p32	BRMUTD
1p31p32 Microdeletion Syndrome	Nfia Haploinsufficiency
Del(1)(P31p32)	Monosomy 1p31p32
Nfia-Related Disorders

Dystonia 3, Torsion, X-Linked

X-Linked Dystonia-Parkinsonism	DYT3
Xdp	Lubag
Dystonia-Parkinsonism, X-Linked	Torsion Dystonia-Parkinsonism, Filipino Type
Dyt-Taf1	X-Linked Dystonia-Parkinsonism Syndrome
X-Linked Torsion Dystonia-Parkinsonism Syndrome	Dystonia Musculorum Deformans
X-Linked Dystonia-Parkinsonism/Lubag	Lubag Syndrome
Dystonia-3	Torsion Dystonia-Parkinsonism Filipino Type
X-Linked Torsion Dystonia 3	Dystonia, Torsion, X-Linked, Type 3

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14474	THAP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	THAP3	VGNC	VGNC:66150
Rattus norvegicus	THAP3	RGD	RGD:1308109
Macaca mulatta	THAP3	VGNC	VGNC:79290
Mus musculus	THAP3	MGD	MGI:1917126
Bos taurus	THAP3	VGNC	VGNC:35822
Canis familiaris	THAP3	VGNC	VGNC:47328

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