F2RL3 - F2R like thrombin or trypsin receptor 3 Gene

Homo sapiens

Also known as PAR4

Gene ID: 9002 | Gene type: protein coding

About F2RL3

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,888,999-16,892,606 (from NCBI)

This gene has 2 transcripts (splice variants), 194 orthologues and 16 paralogues. Broad expression in fat (RPKM 1.9), stomach (RPKM 1.3) and 16 other tissues.

Summary

This gene encodes a member of the Protease-activated Receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung Cancer in human patients. [provided by RefSeq, Sep 2016]

F2RL3 Products(1)

mRNA	Protein	Name
NM_003950.4	NP_003941.2	proteinase-activated receptor 4 preproprotein

F2RL3 Protein Structure

7tm_1

0
100
200
300
385 a.a.

Protein Preferred Names

Protein Names

proteinase-activated receptor 4

F2R like thrombin/trypsin receptor 3	PAR-4
coagulation factor II (thrombin) receptor-like 3	protease-activated receptor-4
thrombin receptor-like 3

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04640	F2RL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04641	F2rl3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04642	F2rl3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	F2RL3	VGNC	VGNC:28686
Mus musculus	F2RL3	MGD	MGI:1298207
Canis familiaris	F2RL3	VGNC	VGNC:40550
Felis catus	F2RL3	VGNC	VGNC:62025
Rattus norvegicus	F2RL3	RGD	RGD:620872

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