TAX1BP1 - Tax1 binding protein 1 Gene

Homo sapiens

Also known as T6BP; TXBP151; CALCOCO3

Gene ID: 8887 | Gene type: protein coding

About TAX1BP1

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,739,373-27,829,767 (from NCBI)

This gene has 13 transcripts (splice variants), 290 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 48.4), thyroid (RPKM 48.2) and 25 other tissues.

Summary

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced Apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with Apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

TAX1BP1 Products(6)

mRNA	Protein	Name
NM_001079864.3	NP_001073333.1	tax1-binding protein 1 isoform 2
NM_001206901.1	NP_001193830.1	tax1-binding protein 1 isoform 2
NM_001206902.2	NP_001193831.1	tax1-binding protein 1 isoform 3
NM_001362794.2	NP_001349723.1	tax1-binding protein 1 isoform 4
NM_001362795.2	NP_001349724.1	tax1-binding protein 1 isoform 5
NM_006024.7	NP_006015.4	tax1-binding protein 1 isoform 1

TAX1BP1 Protein Structure

CALCOCO1

0
200
400
600
789 a.a.

Protein Preferred Names

Protein Names

tax1-binding protein 1

TRAF6-binding protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14227	TAX1BP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TAX1BP1	VGNC	VGNC:47125
Felis catus	TAX1BP1	VGNC	VGNC:102711
Mus musculus	TAX1BP1	MGD	MGI:1289308
Macaca mulatta	TAX1BP1	VGNC	VGNC:78101
Bos taurus	TAX1BP1	VGNC	VGNC:35619
Rattus norvegicus	TAX1BP1	RGD	RGD:708579

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