ALKBH6 - alkB homolog 6 Gene

Homo sapiens

Also known as ABH6

Gene ID: 84964 | Gene type: protein coding

About ALKBH6

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:36,009,120-36,014,239 (from NCBI)

This gene has 19 transcripts (splice variants), 179 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 5.2), spleen (RPKM 4.9) and 25 other tissues.

Summary

Predicted to enable dioxygenase activity and metal ion binding activity. Located in focal adhesion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ALKBH6 Products(5)

mRNA	Protein	Name
NM_001297701.2	NP_001284630.1	alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 isoform 3
NM_001386055.1	NP_001372984.1	alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 isoform 3
NM_001386056.1	NP_001372985.1	alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 isoform 4
NM_032878.5	NP_116267.4	alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 isoform 3
NM_198867.1	NP_942567.1	alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 isoform 1

ALKBH6 Protein Structure

2OG-FeII_Oxy_2

0
100
200
238 a.a.

Protein Preferred Names

Protein Names

alpha-ketoglutarate-dependent dioxygenase alkB homolog 6

alkB, alkylation repair homolog 6

Related Diseases

Diseases

Alias

Noonan Syndrome 5

NS5	Noonan Syndrome, Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00607	ALKBH6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ALKBH6	VGNC	VGNC:37806
Mus musculus	ALKBH6	MGD	MGI:2142037
Rattus norvegicus	ALKBH6	RGD	RGD:1566318
Macaca mulatta	ALKBH6	VGNC	VGNC:69726
Bos taurus	ALKBH6	VGNC	VGNC:25837

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