2. Gene
  3. SH3RF1 - SH3 domain containing ring finger 1 Gene

SH3RF1 - SH3 domain containing ring finger 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as POSH; RNF142; SH3MD2

Gene ID: 57630 | Gene type: protein coding

About SH3RF1

Cytogenetic location: 4q32.3-q33 Genomic coordinates (GRCh38): 4:169,094,259-169,270,956 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 12 paralogues. Ubiquitous expression in thyroid (RPKM 11.9), stomach (RPKM 11.2) and 24 other tissues.

Summary

This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]

SH3RF1 Products(1)

mRNA Protein Name
NM_020870.4 NP_065921.2 E3 ubiquitin-protein ligase SH3RF1

SH3RF1 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (12 - 52)

SH3_9

SH3_9: Variant SH3 domain (141 - 189)

SH3_9

SH3_9: Variant SH3 domain (203 - 255)

SH3_9

SH3_9: Variant SH3 domain (452 - 502)

SH3_9

SH3_9: Variant SH3 domain (837 - 886)

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  • 888 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase SH3RF1

RING-type E3 ubiquitin transferase SH3RF1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12844 SH3RF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SH3RF1 VGNC VGNC:77259
Bos taurus SH3RF1 VGNC VGNC:34579
Mus musculus SH3RF1 MGD MGI:1913066
Felis catus SH3RF1 VGNC VGNC:65113
Canis familiaris SH3RF1 VGNC VGNC:46132
Rattus norvegicus SH3RF1 RGD RGD:735154