2. Gene
  3. MICAL3 - microtubule associated monooxygenase, calponin and LIM domain containing 3 Gene

MICAL3 - microtubule associated monooxygenase, calponin and LIM domain containing 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MICAL-3

Gene ID: 57553 | Gene type: protein coding

About MICAL3

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:17,787,649-18,024,561 (from NCBI)

This gene has 20 transcripts (splice variants), 210 orthologues and 36 paralogues. Ubiquitous expression in testis (RPKM 5.1), brain (RPKM 4.5) and 25 other tissues.

Summary

Enables actin binding activity. Involved in actin filament depolymerization. Located in several cellular components, including Flemming body; intercellular bridge; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MICAL3 Products(3)

mRNA Protein Name
NM_001122731.2 NP_001116203.1 [F-actin]-monooxygenase MICAL3 isoform 3
NM_001136004.3 NP_001129476.1 [F-actin]-monooxygenase MICAL3 isoform 2
NM_015241.3 NP_056056.2 [F-actin]-monooxygenase MICAL3 isoform 1

MICAL3 Protein Structure

FAD_binding_3

FAD_binding_3: FAD binding domain (87 - 124)

CH

CH: Calponin homology (CH) domain (523 - 623)

LIM

LIM: LIM domain (764 - 820)

DUF3585

DUF3585: Protein of unknown function (DUF3585) (1849 - 1989)

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  • 2002 a.a.
Protein Preferred Names Protein Names

[F-actin]-monooxygenase MICAL3

[F-actin]-methionine sulfoxide oxidase MICAL3

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-19893 Antroquinonol Activator 98.61% Phase 2
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13818 Stattic 99.60% Unkown
HY-14393 Emodin Inhibitor 99.20% Yes
HY-10081 GS-6201 Antagonist 98.47% Unkown
HY-12363 U-69593 Agonist ≥99.0% Unkown
HY-132246 WWL123 analogue-1 Inhibitor 98.04% Unkown
HY-14393S Emodin-d4 Inhibitor / Unkown
HY-100839 (RS)-(Tetrazol-5-yl)glycine Agonist / Unkown
HY-14393R Emodin (Standard) Inhibitor / Unkown
HY-N0976 1,11b-Dihydro-11b-hydroxymedicarpin / Unkown
HY-RS08427 MICAL3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MICAL3 MGD MGI:2442733
Macaca mulatta MICAL3 VGNC VGNC:107800
Rattus norvegicus MICAL3 RGD RGD:1359504
Canis familiaris MICAL3 VGNC VGNC:43219
Bos taurus MICAL3 VGNC VGNC:31459