LAPTM4B - lysosomal protein transmembrane 4 beta Gene

Homo sapiens

Also known as LC27; LAPTM4beta

Gene ID: 55353 | Gene type: protein coding

About LAPTM4B

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:97,775,788-97,853,013 (from NCBI)

This gene has 4 transcripts (splice variants), 288 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 97.2), testis (RPKM 52.3) and 23 other tissues.

Summary

Enables ceramide binding activity; Enzyme binding activity; and phosphatidylinositol bisphosphate binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; regulation of lysosomal membrane permeability; and regulation of lysosome organization. Located in several cellular components, including endosome; lysosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

LAPTM4B Products(1)

mRNA	Protein	Name
NM_018407.6	NP_060877.4	lysosomal-associated transmembrane protein 4B

LAPTM4B Protein Structure

Mtp

0
100
200
317 a.a.

Protein Preferred Names

Protein Names

lysosomal-associated transmembrane protein 4B

lysosomal associated protein transmembrane 4 beta

Related Diseases

Diseases

Alias

Gallbladder Cancer

Gallbladder Carcinoma	Gallbladder Neoplasm
Malignant Neoplasm Of Gallbladder	Malignant Tumour Of Gallbladder
Gallbladder Ca	Localized Malignant Gallbladder Neoplasm
Malignant Tumor Of The Gallbladder	Tumor Of The Gallbladder
Cancer Of The Gallbladder	Carcinoma Gallbladder
Carcinoma Of Gallbladder	Gallbladder Neoplasms
Malignant Neoplasm Of Gallbladder Localized	Cancer Of Gallbladder
Primary Malignant Neoplasm Of Gallbladder

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07522	LAPTM4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LAPTM4B	VGNC	VGNC:81664
Canis familiaris	LAPTM4B	VGNC	VGNC:54319
Mus musculus	LAPTM4B	MGD	MGI:1890494
Macaca mulatta	LAPTM4B	VGNC	VGNC:84010
Rattus norvegicus	LAPTM4B	RGD	RGD:1311853

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