1. Gene
  2. NKTR - natural killer cell triggering receptor Gene

NKTR - natural killer cell triggering receptor Gene

Homo sapiens

Also known as p104

Gene ID: 4820 | Gene type: protein coding

About NKTR

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:42,600,612-42,648,735 (from NCBI)

This gene has 18 transcripts (splice variants), 201 orthologues and 22 paralogues. Ubiquitous expression in bone marrow (RPKM 22.3), skin (RPKM 14.4) and 25 other tissues.

Summary

This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008]

NKTR Products(4)

mRNA Protein Name
NM_001349124.2 NP_001336053.1 NK-tumor recognition protein isoform c
NM_001349125.2 NP_001336054.1 NK-tumor recognition protein isoform d
NM_001349126.2 NP_001336055.1 NK-tumor recognition protein isoform e
NM_005385.4 NP_005376.2 NK-tumor recognition protein isoform a

NKTR Protein Structure

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (11 - 175)

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  • 1462 a.a.
Protein Preferred Names Protein Names

NK-tumor recognition protein

NK-TR protein

Related Diseases

Diseases Alias
Theileriasis

Theileriosis

Infection By Theileria

Opioid Abuse

Opioid-Related Disorders

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus NKTR VGNC VGNC:32097
Macaca mulatta NKTR VGNC VGNC:81486
Rattus norvegicus NKTR RGD RGD:2321593
Felis catus NKTR VGNC VGNC:97529
Canis familiaris NKTR VGNC VGNC:56102
Mus musculus NKTR MGD MGI:97346