Eif2ak3 - eukaryotic translation initiation factor 2 alpha kinase 3 Gene

Rattus norvegicus

Also known as PEK

Gene ID: 29702 | Gene type: protein coding

About Eif2ak3

Primary_assembly 4: 102,805,510-102,866,911 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 197 orthologues, 8 paralogues and is associated with 12 phenotypes. Biased expression in Thymus (RPKM 137.6), Kidney (RPKM 111.4) and 9 other tissues.

Summary

Enables HSP90 protein binding activity and eukaryotic translation initiation factor 2alpha kinase activity. Involved in negative regulation of translation in response to stress; protein autophosphorylation; and response to manganese-induced endoplasmic reticulum stress. Located in perinuclear region of cytoplasm. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Eif2ak3 Products(1)

mRNA	Protein	Name
NM_031599.2	NP_113787.1	eukaryotic translation initiation factor 2-alpha kinase 3 precursor

Eif2ak3 Protein Structure

Luminal_EIF2AK3

PKc_like

STKc_EIF2AK3_PERK

0
200
400
600
800
1000
1108 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 2-alpha kinase 3

PRKR-like endoplasmic reticulum kinase

pancreatic eIF2-alpha kinase

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119240	CCT020312	Activator	99.28%	Unkown
HY-RS04244	EIF2AK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04245	Eif2ak3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04246	Eif2ak3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif2ak3	NCBI	NCBI:9451

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