2. Gene
  3. PTPN18 - protein tyrosine phosphatase non-receptor type 18 Gene

PTPN18 - protein tyrosine phosphatase non-receptor type 18 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BDP1; PTP-HSCF

Gene ID: 26469 | Gene type: protein coding

About PTPN18

Cytogenetic location: 2q21.1 Genomic coordinates (GRCh38): 2:130,356,056-130,375,405 (from NCBI)

This gene has 16 transcripts (splice variants), 73 orthologues and 35 paralogues. Ubiquitous expression in lymph node (RPKM 34.1), spleen (RPKM 27.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of Receptor Tyrosine Kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

PTPN18 Products(2)

mRNA Protein Name
NM_001142370.2 NP_001135842.1 tyrosine-protein phosphatase non-receptor type 18 isoform 2
NM_014369.4 NP_055184.2 tyrosine-protein phosphatase non-receptor type 18 isoform 1

PTPN18 Protein Structure

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (56 - 289)

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  • 460 a.a.
Protein Preferred Names Protein Names

tyrosine-protein phosphatase non-receptor type 18

brain-derived phosphatase

Related Diseases

Diseases Alias
Toxic Diffuse Goiter
Erythrocytosis, Familial, 7

ECYT7

Erythrocytosis 7

Familial Erythrocytosis 7

Erythrocytosis, Alpha-Globin Type

Polycythemia, Alpha-Globin Type

Alpha-Globin Type Erythrocytosis

Alpha-Globin Type Polycythemia
Erythrocytosis, Familial, 6

ECYT6

Erythrocytosis 6

Familial Erythrocytosis 6

Erythrocytosis, Beta-Globin Type

Polycythemia, Beta-Globin Type

Beta-Globin Type Erythrocytosis

Beta-Globin Type Polycythemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11420 PTPN18 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PTPN18 MGD MGI:108410
Macaca mulatta PTPN18 VGNC VGNC:76601
Bos taurus PTPN18 VGNC VGNC:33533
Rattus norvegicus PTPN18 RGD RGD:1311586