2. Gene
  3. BRD8 - bromodomain containing 8 Gene

BRD8 - bromodomain containing 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SMAP; p120; SMAP2

Gene ID: 10902 | Gene type: protein coding

About BRD8

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,139,770-138,178,630 (from NCBI)

This gene has 26 transcripts (splice variants) and 291 orthologues. Broad expression in testis (RPKM 45.3), brain (RPKM 10.9) and 23 other tissues.

Summary

The protein encoded by this gene interacts with Thyroid Hormone Receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]

BRD8 Products(6)

mRNA Protein Name
NM_001164326.2 NP_001157798.1 bromodomain-containing protein 8 isoform 4
NM_001300961.3 NP_001287890.1 bromodomain-containing protein 8 isoform 5
NM_001300962.3 NP_001287891.1 bromodomain-containing protein 8 isoform 6
NM_001300966.3 NP_001287895.1 bromodomain-containing protein 8 isoform 7
NM_006696.5 NP_006687.3 bromodomain-containing protein 8 isoform 1
NM_139199.2 NP_631938.2 bromodomain-containing protein 8 isoform 2

BRD8 Protein Structure

Bromodomain

Bromodomain: Bromodomain (725 - 798)

Bromodomain

Bromodomain: Bromodomain (1114 - 1194)

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  • 1235 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 8

skeletal muscle abundant protein 2

Related Diseases

Diseases Alias
Ossifying Fibromyxoid Tumor

Ossifying Fibromyxoid Tumour

Ossifying Fibromyxoma
Endometrial Stromal Tumor

Endometrial Stromal Neoplasm

Endometrial Stromal Tumors
Ovarian Sex-Cord Stromal Tumor

Ovarian Sex Cord Tumor With Annular Tubules

Ovarian Sex Cord-Stromal Tumor

Stromal Tumor Of Ovary
Endometrial Stromal Sarcoma

Ess

Endometrial Stromal Sarcoma, High Grade

Undifferentiated Endometrial Sarcoma

Stromal Sarcoma Of The Corpus Uteri

Sarcoma Endometrial Stromal

Sarcoma, Endometrial Stromal

Undifferentiated Stromal Sarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148116 DN02 Inhibitor 99.17% Unkown
HY-RS01609 BRD8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BRD8 VGNC VGNC:70350
Mus musculus BRD8 MGD MGI:1925906
Felis catus BRD8 VGNC VGNC:60170
Rattus norvegicus BRD8 RGD RGD:1307003