TNIP1 - TNFAIP3 interacting protein 1 Gene

Homo sapiens

Also known as VAN; NAF1; ABIN-1; nip40-1

Gene ID: 10318 | Gene type: protein coding

About TNIP1

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:151,029,943-151,087,685 (from NCBI)

This gene has 21 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 55.9), spleen (RPKM 36.4) and 25 other tissues.

Summary

This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

TNIP1 Products(12)

mRNA	Protein	Name
NM_001252385.2	NP_001239314.1	TNFAIP3-interacting protein 1 isoform 1
NM_001252386.2	NP_001239315.1	TNFAIP3-interacting protein 1 isoform 2
NM_001252390.2	NP_001239319.1	TNFAIP3-interacting protein 1 isoform 3
NM_001252391.2	NP_001239320.1	TNFAIP3-interacting protein 1 isoform 3
NM_001252392.2	NP_001239321.1	TNFAIP3-interacting protein 1 isoform 4
NM_001252393.2	NP_001239322.1	TNFAIP3-interacting protein 1 isoform 4
NM_001258454.2	NP_001245383.1	TNFAIP3-interacting protein 1 isoform 3
NM_001258455.1	NP_001245384.1	TNFAIP3-interacting protein 1 isoform 5
NM_001258456.1	NP_001245385.1	TNFAIP3-interacting protein 1 isoform 6
NM_001364486.2	NP_001351415.1	TNFAIP3-interacting protein 1 isoform 7
NM_001364487.2	NP_001351416.1	TNFAIP3-interacting protein 1 isoform 5
NM_006058.5	NP_006049.3	TNFAIP3-interacting protein 1 isoform 3

Protein Preferred Names

Protein Names

TNFAIP3-interacting protein 1

A20-binding inhibitor of NF-kappa-B activation 1

Related Diseases

Diseases

Alias

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To	Psoriatic Arthropathy
Arthropathic Psoriasis	Arthritis, Psoriatic
Arthritis Psoriatica	PSORAS
Arthritic Psoriasis	Psoriasis Arthropathica
Arthritis Psoriatic	Arthritis, Psoriatic, Susceptibility To

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Psoriasis 14, Pustular

Generalized Pustular Psoriasis	Gpp
Ditra	Acrodermatitis Continua Of Hallopeau
Palmoplantar Pustulosis	PSORS14
Interleukin 36 Receptor Antagonist Deficiency	Psorp
Pustular Psoriasis 14	Deficiency Of Il-36r Antagonist
Acute Generalised Pustular Psoriasis	Deficiency Of The Interleukin-36 Receptor Antagonist
Generalized Pustular Psoriasis Of Von Zumbusch	Von Zumbusch Psoriasis
Deficiency Of Il-36ra	Psoriasis, Pustular, Generalized
Psoriasis, Pustular, Type 14	Pustulosis Of Palms And Soles
Acute Generalized Pustular Psoriasis	Palmoplantar Pustular Psoriasis
Pustulosis Palmaris Et Plantaris	Ppp - [Palmoplantar Pustulosis]
Pustular Psoriasis Of The Palms And Soles	Pustular Bacterid

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14834	TNIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TNIP1	VGNC	VGNC:79057
Bos taurus	TNIP1	VGNC	VGNC:36180
Canis familiaris	TNIP1	VGNC	VGNC:47676
Rattus norvegicus	TNIP1	RGD	RGD:1309380
Mus musculus	TNIP1	MGD	MGI:1926194
Felis catus	TNIP1	VGNC	VGNC:66416

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