RASGRP2 - RAS guanyl releasing protein 2 Gene

Homo sapiens

Also known as CDC25L; CALDAG-GEFI

Gene ID: 10235 | Gene type: protein coding

About RASGRP2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,726,911-64,745,456 (from NCBI)

This gene has 23 transcripts (splice variants), 204 orthologues, 24 paralogues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 28.4), lymph node (RPKM 27.5) and 17 other tissues.

Summary

The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including Ras and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

RASGRP2 Products(4)

mRNA	Protein	Name
NM_001098670.2	NP_001092140.1	RAS guanyl-releasing protein 2 isoform a
NM_001098671.2	NP_001092141.1	RAS guanyl-releasing protein 2 isoform a
NM_001318398.2	NP_001305327.1	RAS guanyl-releasing protein 2 isoform b
NM_153819.1	NP_722541.1	RAS guanyl-releasing protein 2 isoform a

RASGRP2 Protein Structure

RasGEF_N

RasGEF

EF-hand_5

C1_1

0
100
200
300
400
500
609 a.a.

Protein Preferred Names

Protein Names

RAS guanyl-releasing protein 2

F25B3.3 kinase-like protein

Related Diseases

Diseases

Alias

Bleeding Disorder, Platelet-Type, 18

Platelet-Type Bleeding Disorder 18	BDPLT18
Bleeding Disorder Due To Calcium- And Dag-Regulated Guanine Exchange Factor-1 Deficiency	Bleeding Disorder Due To Caldag-Gefi Deficiency
Bleeding Disorder, Platelet Type 18

Leukocyte Adhesion Deficiency, Type Iii

Leukocyte Adhesion Deficiency 3	LAD3
Leukocyte Adhesion Deficiency 1 Variant	Lad1v
Integrin Activation Deficiency Disease	Iadd
Leukocyte Adhesion Deficiency Type Iii	Lad1 Variant
Lad-1 Variant	Lad-Iii
Leukocyte Adhesion Deficiency-1 Variant	Leukocyte Adhesion Deficiency Type 1

Leukocyte Adhesion Deficiency, Type I

Leukocyte Adhesion Deficiency	Leukocyte Adhesion Deficiency 1
LAD1	Lad
Lymphocyte Function-Associated Antigen 1 Immunodeficiency	Leukocyte Adhesion Deficiency Type I
Leukocyte Adhesion Deficiency Type 1	Linear Iga Bullous Dermatosis
Linear Iga Dermatosis	Leukocyte-Adhesion Deficiency Syndrome
Lfa1 Immunodeficiency	Congenital Leukocyte Adherence Deficiency
Lad-I	Linear Iga Disease
Leukocyte Adhesion Deficiency Syndrome	Lad 1
Lfa 1 Immunodeficiency	Linear Immunoglobulin A Dermatosis
Leucocyte Adhesion Deficiency Type 1	Leukocyte Adhesion Molecule Deficiency Type 1

Thrombasthenia

Glanzmann Thrombasthenia 1

Glanzmann Thrombasthenia	Thrombasthenia Of Glanzmann And Naegeli
Glanzmann'S Thrombasthenia	Bdplt2
Platelet Glycoprotein Iib-Iiia Deficiency	Deficiency Of Platelet Fibrinogen Receptor
GT1	Gt
Platelet Fibrinogen Receptor Deficiency	Glycoprotein Complex Iib-Iiia Deficiency
Deficiency Of Glycoprotein Complex Iib-Iiia	Glycoprotein Iib/Iiia Defect
Glanzmann Thrombasthenia, Type A	Thrombasthenia
Bleeding Disorder, Platelet-Type, 2	Gp Iib-Iiia Complex Deficiency
Deficiency Of Gp Iib-Iiia Complex	Platelet-Type Bleeding Disorder 2
Thrombocytasthenia	Deficiency Of Gp 2b 3a Complex
Diacyclothrombopathia 2b 3a	Glanzmann Thrombasthenia Type A
Platelet Fibrinogen Receptor, Deficiency Of	Platelet Glycoprotein 2b 3a Deficiency
Glanzmann Disease	Glanzmann-Naegeli Disorder
Hereditary Hemorrhagic Thrombasthenia	Hereditary Thrombasthenia
Bleeding Disorder Platelet-Type 2

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11694	RASGRP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RASGRP2	VGNC	VGNC:33748
Felis catus	RASGRP2	VGNC	VGNC:104320
Macaca mulatta	RASGRP2	VGNC	VGNC:76672
Rattus norvegicus	RASGRP2	RGD	RGD:1311630
Canis familiaris	RASGRP2	VGNC	VGNC:45372
Mus musculus	RASGRP2	MGD	MGI:1333849

Name
Email *

	Sorry, but the email address you supplied was invalid.