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  4. F-14512

F-14512 is a targeted cytotoxic compound that utilizes the polyamine transport system (PTS) to selectively deliver polyamine-containing drugs to cancer cells. F-14512 combines an epipodophyllotoxin core that targets topoisomerase II with a spermine group that acts as a cell delivery vehicle, with improved selectivity for tumor cells. F-14512 exhibits significant cytotoxicity against cells with high PTS activity and demonstrates high potency in multiple human cell lines (median IC50=0.18 μM). In the MX1 breast tumor xenograft model, F-14512 exhibits potent antitumor activity.

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F-14512 Chemical Structure

F-14512 Chemical Structure

CAS No. : 866874-63-7

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10 mg USD 150 In-stock
25 mg USD 300 In-stock
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Description

F-14512 is a targeted cytotoxic compound that utilizes the polyamine transport system (PTS) to selectively deliver polyamine-containing drugs to cancer cells. F-14512 combines an epipodophyllotoxin core that targets topoisomerase II with a spermine group that acts as a cell delivery vehicle, with improved selectivity for tumor cells. F-14512 exhibits significant cytotoxicity against cells with high PTS activity and demonstrates high potency in multiple human cell lines (median IC50=0.18 μM). In the MX1 breast tumor xenograft model, F-14512 exhibits potent antitumor activity[1].

Molecular Weight

641.75

Formula

C33H47N5O8
CAS No.
SMILES

O=C1[C@]2([H])[C@H](C3=CC(OC)=C(O)C(OC)=C3)C4=CC(OCO5)=C5C=C4[C@@H](NC(CNCCCNCCCCNCCCN)=O)[C@@]2([H])CO1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (194.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5582 mL 7.7912 mL 15.5824 mL
5 mM 0.3116 mL 1.5582 mL 3.1165 mL
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Purity & Documentation
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Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5582 mL 7.7912 mL 15.5824 mL 38.9560 mL
5 mM 0.3116 mL 1.5582 mL 3.1165 mL 7.7912 mL
10 mM 0.1558 mL 0.7791 mL 1.5582 mL 3.8956 mL
15 mM 0.1039 mL 0.5194 mL 1.0388 mL 2.5971 mL
20 mM 0.0779 mL 0.3896 mL 0.7791 mL 1.9478 mL
25 mM 0.0623 mL 0.3116 mL 0.6233 mL 1.5582 mL
30 mM 0.0519 mL 0.2597 mL 0.5194 mL 1.2985 mL
40 mM 0.0390 mL 0.1948 mL 0.3896 mL 0.9739 mL
50 mM 0.0312 mL 0.1558 mL 0.3116 mL 0.7791 mL
60 mM 0.0260 mL 0.1299 mL 0.2597 mL 0.6493 mL
80 mM 0.0195 mL 0.0974 mL 0.1948 mL 0.4869 mL
100 mM 0.0156 mL 0.0779 mL 0.1558 mL 0.3896 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

F-14512866874-63-7F14512F 14512OthersantitumorMX1 human breast tumor xenograft modelpolyamine transport systemPTSInhibitorinhibitorinhibit

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