EPI-X4 (Synonyms: hSA(408–423) peptide)

Cat. No.: HY-P10415: FAQs
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EPI-X4 (hSA408–423 peptide) is an antagonist for C-X-C motif chemokine receptor 4 (CXCR4) with IC₅₀ of 8.6 μM. EPI-X4 blocks the CXCL12-mediated signaling, inhibits chemokine-mediated migration and invasion of leukemia cell. EPI-X4 exhibits anti-inflammatory activity in mouse model. EPI-X4 exhibits antiviral activity against CXCR4-tropic HIV with IC₅₀ of 8.6 μM.

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EPI-X4 Chemical Structure

CAS No. : 930280-31-2

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Purity & Documentation
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Description

IC₅₀ & Target

CXCR4

8.6 μM (IC₅₀)

Molecular Weight

1830.18

Formula

C₈₄H₁₄₄N₂₂O₂₃

CAS No.

930280-31-2

Sequence

Leu-Val-Arg-Tyr-Thr-Lys-Lys-Val-Pro-Gln-Val-Ser-Thr-Pro-Thr-Leu

Sequence Shortening

LVRYTKKVPQVSTPTL

SMILES

O=C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N3[C@@H](CCC3)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zirafi O, et al., Discovery and characterization of an endogenous CXCR4 antagonist. Cell Rep. 2015 May 5;11(5):737-47. [Content Brief]

EPI-X4 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EPI-X4930280-31-2hSA(408–423) peptideCXCRCXC chemokine receptorsC-X-C motif chemokine receptorsDU145Jurkatatopic dermatitisasthmaleukemiaC57BL/6 mouseInhibitorinhibitorinhibit

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