Molnupiravir (Synonyms: EIDD-2801; MK-4482)

Name: Molnupiravir
Brand: MedChemExpress
SKU: HY-135853
Rating: 5.0 (40 reviews)

Cat. No.: HY-135853 Pureté: 99.94%: FAQs
Fiche technique SDS COA Instruction de manipulation

Molarity Calculator

Molnupiravir (EIDD-2801) is an orally bioavailable proagent of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza.

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Molnupiravir Chemical Structure

CAS No. : 2492423-29-5

Size	Prix	Stock	Quantité

Échantillon gratuit (0.1 - 0.5 mg)		Appliquer maintenant
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 77	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 77	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 45	En stock	Estimated Time of Arrival: December 31
10 mg	USD 70	En stock	Estimated Time of Arrival: December 31
25 mg	USD 90	En stock	Estimated Time of Arrival: December 31
50 mg	USD 150	En stock	Estimated Time of Arrival: December 31
100 mg	USD 250	En stock	Estimated Time of Arrival: December 31
200 mg	USD 450	En stock	Estimated Time of Arrival: December 31
500 mg	USD 950	En stock	Estimated Time of Arrival: December 31
1 g	USD 1550	En stock	Estimated Time of Arrival: December 31
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10 g		Obtenir un devis

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Based on 40 publication(s) in Google Scholar

Other Forms of Molnupiravir:

Molnupiravir-d₇ In-stock

40 Publications Citing Use of MCE Molnupiravir

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Activité biologique
Pureté et documentation
Références
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Description

In Vivo

Molnupiravir (50-500 mg/kg; p.o.; every 12 hours for 3 days) is robustly antiviral and able to prevent SARS-CoV replication and disease^[1].
Molnupiravir (7 mg/kg; p.o.; twice daily for 3.5 days) significantly reduces shed virus load and duration of fever^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice (intranasal infection with SARS-CoV)^[1]
Dosage:	50, 150, 500 mg/kg
Administration:	Oral; every 12 hours for 3 days
Result:	Body weight loss is significantly diminished or prevented.

Animal Model:	Ca/09-infected female ferrets^[1]
Dosage:	7 mg/kg
Administration:	Oral; twice daily for 3.5 days
Result:	Shed virus load and duration of fever were significantly reduced.

Essai clinique

Masse moléculaire

329.31

Formule

C₁₃H₁₉N₃O₇

CAS No.

2492423-29-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(N([C@@]1([H])[C@H](O)[C@H](O)[C@@]([H])(COC(C(C)C)=O)O1)C=C2)NC2=NO

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (151.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 12.5 mg/mL (37.96 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0367 mL	15.1833 mL	30.3665 mL
5 mM	0.6073 mL	3.0367 mL	6.0733 mL
10 mM	0.3037 mL	1.5183 mL	3.0367 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 25 mg/mL (75.92 mM); Clear solution; Need ultrasonic
Protocol 2

Add each solvent one by one: 10% PEG400 2.5% Ethoxylated hydrogenated castor oil 87.5% Water
Solubility: 12.05 mg/mL (36.59 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureté et documentation

Purity: 99.94%

Select Batch:

Fiche technique (277 KB) SDS (393 KB)

COA (253 KB) RP-HPLC (3404 KB) Elemental Analysis Report (110 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Sheahan TP, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med. 2020 Apr 6. pii: eabb5883. [Content Brief]

[2]. Toots M, et al. Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci Transl Med. 2019 Oct 23;11(515). pii: eaax5866. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.0367 mL	15.1833 mL	30.3665 mL	75.9163 mL
	5 mM	0.6073 mL	3.0367 mL	6.0733 mL	15.1833 mL
	10 mM	0.3037 mL	1.5183 mL	3.0367 mL	7.5916 mL
	15 mM	0.2024 mL	1.0122 mL	2.0244 mL	5.0611 mL
	20 mM	0.1518 mL	0.7592 mL	1.5183 mL	3.7958 mL
	25 mM	0.1215 mL	0.6073 mL	1.2147 mL	3.0367 mL
	30 mM	0.1012 mL	0.5061 mL	1.0122 mL	2.5305 mL
DMSO	40 mM	0.0759 mL	0.3796 mL	0.7592 mL	1.8979 mL
	50 mM	0.0607 mL	0.3037 mL	0.6073 mL	1.5183 mL
	60 mM	0.0506 mL	0.2531 mL	0.5061 mL	1.2653 mL
	80 mM	0.0380 mL	0.1898 mL	0.3796 mL	0.9490 mL
	100 mM	0.0304 mL	0.1518 mL	0.3037 mL	0.7592 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molnupiravir Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Molnupiravir (Synonyms: EIDD-2801; MK-4482)

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Other Forms of Molnupiravir:

Molnupiravir Related Antibodies

40 Publications Citing Use of MCE Molnupiravir

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Activité biologique

Pureté et documentation

Références

Avis client

Calculateur de molarité

Calculateur de dilution

Complete Stock Solution Preparation Table

Molnupiravir Related Classifications

Keywords:

Vos produits récemment consultés:

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