2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
  3. ROCK
  4. DJ4

DJ4 is a ATP-competitive inhibitor of ROCK1/2 (IC50 values:5 and 50 nM) and MRCKα/β (IC50 values:10 and 100 nM). DJ4 blocks stress fiber formation and induces cell apoptosis. DJ4 can be used for study of cancer.

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DJ4 Chemical Structure

DJ4 Chemical Structure

CAS No. : 1681020-24-5

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Description

DJ4 is a ATP-competitive inhibitor of ROCK1/2 (IC50 values:5 and 50 nM) and MRCKα/β (IC50 values:10 and 100 nM). DJ4 blocks stress fiber formation and induces cell apoptosis. DJ4 can be used for study of cancer[1].

IC50 & Target

ROCK1

5 nM (IC50)

ROCK2

50 nM (IC50)

Molecular Weight

348.42

Formula

C19H16N4OS
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1N/C(S/C1=C/C2=CNC3=C2C=CC=N3)=N\CCC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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DJ4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DJ41681020-24-5DJ 4DJ-4ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKstress fiberscancerInhibitorinhibitorinhibit

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