Crobenetine hydrochloride (Synonyms: BIII-890 hydrochloride; BIII-890 CL)

Cat. No.: HY-16923A: FAQs
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Crobenetine hydrochloride (BIII-890 hydrochloride) is the hydrochloride form of Crobenetine (HY-16923). Crobenetine hydrochloride is a selective inhibitor for Na⁺ channel. Crobenetine hydrochloride displaces ^3HBTX from site 2 of the Na⁺ channel (IC₅₀=49 nM) in rat brain synaptosomes, exhibits only low binding affinity for other receptors and ion channels. Crobenetine hydrochloride protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents.

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Crobenetine hydrochloride Chemical Structure

CAS No. : 221018-88-8

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Description	Crobenetine hydrochloride (BIII-890 hydrochloride) is the hydrochloride form of Crobenetine (HY-16923). Crobenetine hydrochloride is a selective inhibitor for Na⁺ channel. Crobenetine hydrochloride displaces ^3HBTX from site 2 of the Na⁺ channel (IC₅₀=49 nM) in rat brain synaptosomes, exhibits only low binding affinity for other receptors and ion channels. Crobenetine hydrochloride protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents^[1].
Molecular Weight	416.00
Formula	C₂₅H₃₄ClNO₂
CAS No.	221018-88-8
SMILES	OC1=C2C([C@@]3(CCN([C@]([H])(C2)C3(C)C)C[C@H](C)OCC4=CC=CC=C4)C)=CC=C1.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. A J Carter, et al. Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4944-9. [Content Brief]

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crobenetine221018-88-8BIII-890 BIII-890 CLBIII890BIII 890Sodium ChannelNa channelsNa+ channelsBenzomorphanBTXbrain synaptosomesdeleteriousfocal cerebral ischemiaInhibitorinhibitorinhibit

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Crobenetine hydrochloride (Synonyms: BIII-890 hydrochloride; BIII-890 CL)

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