2. Metabolic Enzyme/Protease
  3. CETP
  4. CP-532623

CP-532623 is a CETP inhibitor and elevates high-density lipoprotein cholesterolion. CP-532623 is a close structural analogue of Torcetrapib. CP-532623 has highly lipophilic properties.

For research use only. We do not sell to patients.

CP-532623 Chemical Structure

CP-532623 Chemical Structure

CAS No. : 261947-38-0

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CP-532623 Related Antibodies

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Description

CP-532623 is a CETP inhibitor and elevates high-density lipoprotein cholesterolion. CP-532623 is a close structural analogue of Torcetrapib. CP-532623 has highly lipophilic properties[1][2][3].

IC50 & Target

CETP[1]
In Vitro

CP-532623 is highly lymphatically transported (28% of dose), and lymphatic transport is closely correlated with drug affinity for ex-vivo lymph lipoproteins or triglyceride emulsions and poorly relates to solubility in mixtures of lipoprotein core and/or surface lipids. CP-532623 alters the kinetics of lymph lipid transport and decreases lymph lipid transport in chylomicrons[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CP-532623 Related Antibodies
In Vivo

CP-532623 (50 mg; oral administration; adult male greyhound dogs) treatment substantially transports into the lymphatic system (>25% dose) in fed and fasted dogs. Food enhances oral bioavailability (from 44 to 58%, respectively) and the proportion of the absorbed dose transports via the lymph (from 61 to 86% and from 68 to 83%, respectively). Lymphatic triglyceride transport is significantly lower in fed dogs administered CP-532623[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male greyhound dogs (27-39 kg)[3]
Dosage: 50 mg
Administration: Oral administration with a long-chain lipid formulation to fed lymphcannulated
Result: Substantially transported into the lymphatic system (>25% dose) in fed and fasted dogs. Food enhanced oral bioavailability and the proportion of the absorbed dose transported via the lymph.
Molecular Weight

598.50

Formula

C27H27F9N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1[C@H](CC)C[C@H](N(C(C)=O)CC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C3=C1C=CC(C(F)(F)F)=C3)OC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 20 mg/mL (33.42 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6708 mL 8.3542 mL 16.7084 mL
5 mM 0.3342 mL 1.6708 mL 3.3417 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6708 mL 8.3542 mL 16.7084 mL 41.7711 mL
5 mM 0.3342 mL 1.6708 mL 3.3417 mL 8.3542 mL
10 mM 0.1671 mL 0.8354 mL 1.6708 mL 4.1771 mL
15 mM 0.1114 mL 0.5569 mL 1.1139 mL 2.7847 mL
20 mM 0.0835 mL 0.4177 mL 0.8354 mL 2.0886 mL
25 mM 0.0668 mL 0.3342 mL 0.6683 mL 1.6708 mL
30 mM 0.0557 mL 0.2785 mL 0.5569 mL 1.3924 mL
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CP-532623 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-532623261947-38-0CP532623CP 532623CETPCholesteryl ester transfer proteinLymphaticallylipoproteinstriglyceridelipophilicHDL-CTorcetrapiboralbioavailabilityInhibitorinhibitorinhibit

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