Cortistatin-29 

Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds with high affinity all somatostatin (SS) receptor subtypes and shows IC₅₀ values of 2.8, 7.1, 0.2, 3.0, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects^[1][2][3][4].

Cortistatin 29 (1-2 µg) alleviates chronic neuropathic pain in mouse^[1].
Cortistatin 29 (1 nmol/mouse; i.p.; three times weekly) shows anti-fibrotic effects in mouse^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3540.04

C₁₆₁H₂₄₀N₄₆O₄₁S₂

1815618-17-7

{Glp}-Glu-Arg-Pro-Pro-Leu-Gln-Gln-Pro-Pro-His-Arg-Asp-Lys-Lys-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys (disulfide bridge: Cys17-Cys28)

{Glp}-ERPPLQQPPHRDKKPCKNFFWKTFSSCK (disulfide bridge: Cys17-Cys28)

O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)CC2=CC=CC=C2)=O)CO)=O)CO)=O)C(N[C@H](C(O)=O)CCCCN)=O)NC([C@H]3N(CCC3)C([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC4=CN=CN4)NC([C@H]5N(CCC5)C([C@H]6N(CCC6)C([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H]7N(CCC7)C([C@H]8N(CCC8)C([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC([C@@H]9CCC(N9)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCCN)=O)CC(N)=O)=O)CC%10=CC=CC=C%10)=O)CC%11=CC=CC=C%11)N[C@H]1CC%12=CNC%13=CC=CC=C%12%13.OC(C(F)(F)F)=O.[x]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Falo CP, et al. The Neuropeptide Cortistatin Alleviates Neuropathic Pain in Experimental Models of Peripheral Nerve Injury. Pharmaceutics. 2021 Jun 24;13(7):947.  [Content Brief]

  [2]. Baranowska B, et al. Direct effect of cortistatin on GH release from cultured pituitary cells in the rat. Neuro Endocrinol Lett. 2006 Feb-Apr;27(1-2):153-6.  [Content Brief]

  [3]. Spier AD, et al. Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res Brain Res Rev. 2000 Sep;33(2-3):228-41.  [Content Brief]

  [4]. Benitez R, et al. Cortistatin regulates fibrosis and myofibroblast activation in experimental hepatotoxic- and cholestatic-induced liver injury. Br J Pharmacol. 2022 May;179(10):2275-2296.  [Content Brief]