2. Protein Tyrosine Kinase/RTK
  3. Src
  4. Cisplatin/Dasatinib prodrug-1

Cisplatin/Dasatinib prodrug-1 (Compound 3) is a prodrug of Cisplatin (HY-17394) and Dasatinib (HY-10181). Cisplatin/Dasatinib prodrug-1 exhibits antiproliferative activity against A2780, MDA-MB-231, MCF7, HCT116, RD, Thp1 and HL60 cancer cells with IC50s of 0.1, 0.1, 0.36, 2.0, 0.4, 0.3 and 0.25 μM, respectively.

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Cisplatin/Dasatinib prodrug-1 Chemical Structure

Cisplatin/Dasatinib prodrug-1 Chemical Structure

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Cisplatin/Dasatinib prodrug-1 Related Antibodies

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Description

Cisplatin/Dasatinib prodrug-1 (Compound 3) is a prodrug of Cisplatin (HY-17394) and Dasatinib (HY-10181). Cisplatin/Dasatinib prodrug-1 exhibits antiproliferative activity against A2780, MDA-MB-231, MCF7, HCT116, RD, Thp1 and HL60 cancer cells with IC50s of 0.1, 0.1, 0.36, 2.0, 0.4, 0.3 and 0.25 μM, respectively[1].

Molecular Weight

994.25

Formula

C33H42Cl3N9O6PtS
SMILES

[NH3][Pt](Cl)(OC(OCCN1CCN(C2=CC(NC3=NC=C(C(NC4=C(C=CC=C4C)Cl)=O)S3)=NC(C)=N2)CC1)=O)([NH3])(OC(CCCC5=CC=CC=C5)=O)Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cisplatin/Dasatinib prodrug-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cisplatin/Dasatinib prodrug-1SrcCisplatinDasatinibprodrugA2780MDA-MB-231MCF7HCT116RDThp1HL60MRC5pd30Inhibitorinhibitorinhibit

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