2. GPCR/G Protein Neuronal Signaling Anti-infection
  3. 5-HT Receptor SARS-CoV
  4. Cinanserin

Cinanserin (SQ 10643) is a potent and selective 5-HT2 antagonist with Ki values of 41, 3500 nM for 5-HT2, 5-HT1, respectively. Cinanserin also is a SARS-CoV 3CLpro inhibitor with an KD value of 49.4, 18.2 µM for SARS-CoV 3CLpro, HCoV-229E 3CLpro, respectively. Cinanserin reduces systemic burn edema levels.

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Cinanserin Chemical Structure

Cinanserin Chemical Structure

CAS No. : 1166-34-3

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Cinanserin Related Antibodies

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Description

Cinanserin (SQ 10643) is a potent and selective 5-HT2 antagonist with Ki values of 41, 3500 nM for 5-HT2, 5-HT1, respectively. Cinanserin also is a SARS-CoV 3CLpro inhibitor with an KD value of 49.4, 18.2 µM for SARS-CoV 3CLpro, HCoV-229E 3CLpro, respectively. Cinanserin reduces systemic burn edema levels[1][2][3].

IC50 & Target[2][3]

5-HT2 Receptor

41 nM (Ki)

5-HT1 Receptor

3500 nM (Ki)

SARS-CoV 3CLpro

49.4 μM (Kd)

In Vivo

Cinanserin (5 mg/kg; i.v.) treatment significantly reduces systemic burn edema levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (250 g) underwent thermal injury[1]
Dosage: 5 mg/kg
Administration: Intravenous injection; for 2 hours
Result: Significantly reduced systemic burn edema to shamburn levels, leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin.
Molecular Weight

340.48

Formula

C20H24N2OS
CAS No.
SMILES

O=C(NC1=CC=CC=C1SCCCN(C)C)/C=C/C2=CC=CC=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cinanserin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cinanserin1166-34-35-HT ReceptorSARS-CoVSerotonin Receptor5-hydroxytryptamine ReceptorSARS coronavirusMRC-5 cellsHCoV-229Eburn edemaInhibitorinhibitorinhibit

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