Carbazomycin B 

Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits cell growth of MCF-7, KB, NCI H187, and Vero cells with IC₅₀ values of 8.4, 8.6, 4.2, and 48.9 µM, respectively. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC₅₀ Of 1.5 µM^[1]sup>[2]sup>[3]sup>[4].

241.29

C₁₅H₁₅NO₂

75139-38-7

OC1=C(C(C)=C(C)C2=C1C3=C(C=CC=C3)N2)OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yamasaki K, Kaneda M, Watanabe K, et al. New antibiotics, carbazomycins A and B. III. Taxonomy and biosynthesis. J Antibiot (Tokyo). 1983;36(5):552-558.  [Content Brief]

  [2]. Sakano K, et al. New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological properties. J Antibiot (Tokyo). 1980;33(7):683-689.  [Content Brief]

  [3]. Naid T, et al. Carbazomycins C, D, E and F, minor components of the carbazomycin complex. J Antibiot (Tokyo). 1987;40(2):157-164.  [Content Brief]

  [4]. Hook DJ, et al. Identification of the inhibitory activity of carbazomycins B and C against 5-lipoxygenase, a new activity for these compounds. J Antibiot (Tokyo). 1990 Oct;43(10):1347-8.  [Content Brief]