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C-Type Natriuretic Peptide (CNP) (1-22), human TFA 

Cat. No.: HY-P1237A Purity: 98.10%
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C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor.

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C-Type Natriuretic Peptide (CNP) (1-22), human TFA Chemical Structure

C-Type Natriuretic Peptide (CNP) (1-22), human TFA Chemical Structure

CAS No. : 1966153-17-2

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Based on 1 publication(s) in Google Scholar

Other Forms of C-Type Natriuretic Peptide (CNP) (1-22), human TFA:

C-Type Natriuretic Peptide (CNP) (1-22), human TFA Related Antibodies

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1 Publications Citing Use of MCE C-Type Natriuretic Peptide (CNP) (1-22), human TFA

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Description

C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor[1][2][3].

IC50 & Target[1]

NPR-B

 

In Vitro

C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) (0.01, 0.1, 1, 10, 100, 1000 nM) increases cGMP production in CHO cells expressing human NPR-B in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C-Type Natriuretic Peptide (CNP) (1-22), human TFA Related Antibodies
In Vivo

PK parameters of CNP immunoreactivity after a single intravenous administration of C-Type Natriuretic Peptide (CNP) (1-22), human[1]:

Dose
(nM/kg)		 AUC0-∞
(pM·min/mL)		 MRT0-∞
(min)		 T1/2
(min)		 CLtot
(mL/min/kg)		 Vdss
(mL/kg)
20 320±54 1.02±0.18 1.42±0.45 63.9±11.9 64.2±5.1
PK parameters of CNP immunoreactivity after a single subcutaneous administration of C-Type Natriuretic Peptide (CNP) (1-22), human[1]:
Dose
(nM/kg)		 Cmax
(pM/mL)		 Tmax
(min)		 AUC0-∞
(pM·min/mL)		 MRT0-∞
(min)		 T1/2
(min)		 BA
(%)
50 9.02±3.74 5.0±0.0 152±73 13.9±3.4 10.0±5.0 19±9
Each value represents the mean±SD of 3 rats. MRT=mean residence time, CLtot=total clearance, T1/2=half-life period, BA=bioavailability.
i.c.v. administration of C-Type Natriuretic Peptide (CNP) (1-22) in a dose of 2 nM induces an increase in the severity of picrotoxin-kindled convulsions 24 and 48 hrs after application of the peptide[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

2311.62

Formula

C95H158F3N27O30S3
CAS No.
Unlabeled Cas

Appearance

Solid

Color

White to off-white

Sequence Shortening

GLSKGCFGLKLDRIGSMSGLGC (Disulfide bridge: Cys6-Cys22)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 2 mg/mL (0.87 mM; Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References
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C-Type Natriuretic Peptide (CNP) (1-22), human TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C-Type Natriuretic Peptide (CNP) (1-22), human1966153-17-2OthersCNPcAMP synthesisheart transplantdeveloping kidneyhypertrophied kidneyseizure syndromeInhibitorinhibitorinhibit

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