2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling MAPK/ERK Pathway
  3. JAK STAT p38 MAPK
  4. Butyzamide

Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Butyzamide Chemical Structure

Butyzamide Chemical Structure

CAS No. : 1110767-45-7

Size Prix Stock Quantité
5 mg USD 850 En stock
10 mg USD 1350 En stock
25 mg USD 2800 En stock
50 mg USD 4500 En stock
100 mg USD 6900 En stock
200 mg   Obtenir un devis  
500 mg   Obtenir un devis  

* Veuillez sélectionner la quantité avant d'ajouter des articles.

This product is a controlled substance and not for sale in your territory.

Avis client

Based on 1 publication(s) in Google Scholar

Butyzamide Related Antibodies

Top Publications Citing Use of Products

Voir tous les produits spécifiques à Isoform JAK:

Voir toutes les isoformes

Voir tous les produits spécifiques à Isoform STAT:

Voir toutes les isoformes

Voir tous les produits spécifiques à Isoform p38 MAPK:

Voir toutes les isoformes

  • Activité biologique

  • Pureté et documentation

  • Références

  • Avis client

Description

Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay[1].

IC50 & Target

JAK2

 

STAT3

 

STAT5

 

In Vitro

Butyzamide (3 μM; 15 min) induces the phosphorylation of JAK2, STAT3, STAT5 and MAPK in Ba/F3-hMpl cells[1].
Butyzamide (3 μM; 48 h) induces colony-forming unit-megakaryocyte and polyploid meggakaryocytes from human CD34+ hematopoietic progenitor cellls[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Butyzamide Related Antibodies
In Vivo

Butyzamide (10 mg/kg, 50 mg/kg; p.o.; once daily for 20 days) increases human platelets in NOG mice transplanted with human fetal liver-derived CD34+ cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Masse moléculaire

591.55

Formule

C29H32Cl2N2O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCOC(C(C)(C)C)C1=CC=CC(C2=CSC(NC(C3=CC(Cl)=C(/C=C(C(O)=O)\C)C(Cl)=C3)=O)=N2)=C1OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvant et solubilité
In Vitro: 

DMSO : 100 mg/mL (169.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6905 mL 8.4524 mL 16.9047 mL
5 mM 0.3381 mL 1.6905 mL 3.3809 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6905 mL 8.4524 mL 16.9047 mL 42.2619 mL
5 mM 0.3381 mL 1.6905 mL 3.3809 mL 8.4524 mL
10 mM 0.1690 mL 0.8452 mL 1.6905 mL 4.2262 mL
15 mM 0.1127 mL 0.5635 mL 1.1270 mL 2.8175 mL
20 mM 0.0845 mL 0.4226 mL 0.8452 mL 2.1131 mL
25 mM 0.0676 mL 0.3381 mL 0.6762 mL 1.6905 mL
30 mM 0.0563 mL 0.2817 mL 0.5635 mL 1.4087 mL
40 mM 0.0423 mL 0.2113 mL 0.4226 mL 1.0565 mL
50 mM 0.0338 mL 0.1690 mL 0.3381 mL 0.8452 mL
60 mM 0.0282 mL 0.1409 mL 0.2817 mL 0.7044 mL
80 mM 0.0211 mL 0.1057 mL 0.2113 mL 0.5283 mL
100 mM 0.0169 mL 0.0845 mL 0.1690 mL 0.4226 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Butyzamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Butyzamide1110767-45-7JAKSTATp38 MAPKJanus kinaseInhibitorinhibitorinhibit

Vos produits récemment consultés:

Demande en ligne

Your information is safe with us. * Required Fields.

Nom du produit

  

Salutation

Nom du demandeur *

 

Adresse électronique *

Numéro de téléphone *

 

Nom de l'organisation *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Nom du produit:
Butyzamide
Cat. No.:
HY-148748
Quantité:
MCE Japan Authorized Agent:

Avis client

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nom du produit

  

Lot #

Nom du demandeur *

 

Adresse électronique *

Numéro de téléphone

 

Department *

Nom de l'organisation *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.