2. Cell Cycle/DNA Damage Apoptosis
  3. DNA Alkylator/Crosslinker Apoptosis
  4. Busulfan-d8

Busulfan-d8 is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

For research use only. We do not sell to patients.

Busulfan-d<sub>8</sub> Chemical Structure

Busulfan-d8 Chemical Structure

CAS No. : 116653-28-2

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1 mg USD 77 In-stock
5 mg USD 270 In-stock
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Based on 1 publication(s) in Google Scholar

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Busulfan-d8 Related Antibodies

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Description

Busulfan-d8 is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3].

Molecular Weight

254.35

Formula

C6H6D8O6S2
CAS No.
Unlabeled Cas

55-98-1
Appearance

Solid

Color

White to off-white

SMILES

CS(=O)(OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])OS(C)(=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 16.7 mg/mL (65.66 mM)

DMSO : ≥ 16.7 mg/mL (65.66 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO:PBS (pH 7.2) (1:1) : ≥ 0.5 mg/mL (1.97 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9316 mL 19.6580 mL 39.3159 mL
5 mM 0.7863 mL 3.9316 mL 7.8632 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO:PBS (pH 7.2) (1:1) / DMF / DMSO 1 mM 3.9316 mL 19.6580 mL 39.3159 mL 98.2898 mL
DMF / DMSO 5 mM 0.7863 mL 3.9316 mL 7.8632 mL 19.6580 mL
10 mM 0.3932 mL 1.9658 mL 3.9316 mL 9.8290 mL
15 mM 0.2621 mL 1.3105 mL 2.6211 mL 6.5527 mL
20 mM 0.1966 mL 0.9829 mL 1.9658 mL 4.9145 mL
25 mM 0.1573 mL 0.7863 mL 1.5726 mL 3.9316 mL
30 mM 0.1311 mL 0.6553 mL 1.3105 mL 3.2763 mL
40 mM 0.0983 mL 0.4914 mL 0.9829 mL 2.4572 mL
50 mM 0.0786 mL 0.3932 mL 0.7863 mL 1.9658 mL
60 mM 0.0655 mL 0.3276 mL 0.6553 mL 1.6382 mL
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Busulfan-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Busulfan-d8116653-28-2DNA Alkylator/CrosslinkerApoptosisAlkylatingantineoplasticDNA damagecross-linkingthioredoxin reductaseimmunosuppressivemyeloablative chemotherapeutic drugInhibitorinhibitorinhibit

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