BPIPP 

BPIPP is a guanylyl cyclase type C (GC-C) and adenylyl cyclase inhibitor that can suppress cyclic nucleotide synthesis. BPIPP inhibits chloride-ion transport stimulated by activation of guanylyl or adenylyl cyclases, and has the potential for diarrhea research^[1].

BPIPP suppresses stable toxin (STa)-stimulated cGMP accumulation by decreasing GC-C activation in intact T84 human colorectal carcinoma cells. BPIPP inhibits stimulation of guanylyl cyclases, including types A and B and soluble isoform in various cells. BPIPP suppresses stimulation of adenylyl cyclase and significantly decreases the activities of adenylyl cyclase toxin of Bordetella pertussis and edema toxin of Bacillus anthracis. The effects of BPIPP on cyclic nucleotide synthesis were observed only in intact cells^[1].
BPIPP inhibits chloride-ion transport stimulated by activation of guanylyl or adenylyl cyclases and suppressed STa-induced fluid accumulation in an in vivo rabbit intestinal loop model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

450.28

C₂₂H₁₆BrN₃O₃

325746-94-9

O=C1C2=C(C3=CC=CC=C13)NC(N(C(N(C)C4=O)=O)C)=C4C2C5=CC(Br)=CC=C5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Alexander Y Kots, et al. Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: Application for treatment of diarrhea. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8440-5.  [Content Brief]