Prolyl endopeptidase-like

Definition:

Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex. May play a role in the regulation of synaptic vesicle exocytosis.

References:

[1]. Luc Régal, et al. PREPL deficiency with or without cystinuria causes a novel myasthenic syndrome. Neurology. 2014 Apr 8;82(14):1254-60. [Content Brief]

[2]. Luc Régal, et al. PREPL deficiency: delineation of the phenotype and development of a functional blood assay. Genet Med. 2018 Jan;20(1):109-118. [Content Brief]

[3]. Z Szeltner, et al. The PREPL A protein, a new member of the prolyl oligopeptidase family, lacking catalytic activity. Cell Mol Life Sci. 2005 Oct;62(19-20):2376-81. [Content Brief]

[4]. Jaak Jaeken, et al. Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome. Am J Hum Genet. 2006 Jan;78(1):38-51. [Content Brief]

[5]. Karthikeyan Radhakrishnan, et al. Trans-Golgi network morphology and sorting is regulated by prolyl-oligopeptidase-like protein PREPL and the AP-1 complex subunit μ1A. J Cell Sci. 2013 Mar 1;126(Pt 5):1155-63. [Content Brief]

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