Pleckstrin homology domain-containing family F member 2

Definition:

May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis.

References:

[1]. Wen-Jie Lin, et al. Phafin2 modulates the structure and function of endosomes by a Rab5-dependent mechanism. Biochem Biophys Res Commun. 2010 Jan 1;391(1):1043-8. [Content Brief]

[2]. Nina Marie Pedersen, et al. The PtdIns3P-binding protein Phafin 2 mediates epidermal growth factor receptor degradation by promoting endosome fusion. Traffic. 2012 Nov;13(11):1547-63. [Content Brief]

[3]. Changfei Li, et al. EAPF/Phafin-2, a novel endoplasmic reticulum-associated protein, facilitates TNF-alpha-triggered cellular apoptosis through endoplasmic reticulum-mitochondrial apoptotic pathway. J Mol Med (Berl). 2008 Apr;86(4):471-84. [Content Brief]

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