Phosphatidate cytidylyltransferase 1

Definition:

Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol. Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs. Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis. Positively regulates the differentiation and development of adipocytes (By similarity).

References:

[1]. Kenneth D'Souza, et al. Distinct properties of the two isoforms of CDP-diacylglycerol synthase. Biochemistry. 2014 Dec 2;53(47):7358-67. [Content Brief]

[2]. Yanfei Qi, et al. CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development. J Lipid Res. 2016 May;57(5):767-80. [Content Brief]

[3]. Yanqing Xu, et al. CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms. J Biol Chem. 2019 Nov 8;294(45):16740-16755. [Content Brief]

[4]. A Lykidis, et al. The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. J Biol Chem. 1997 Dec 26;272(52):33402-9. [Content Brief]

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