2. Cell Cycle/DNA Damage Epigenetics
  3. Aurora Kinase
  4. Binucleine 2

Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki=0.36 μM), a kinase involved in cell division. It is specific for Drosophila Aurora B kinase, inhibiting it in a dose-dependent manner, with minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 μM. Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells. It prevents Drosophila S2 cells from assembling a contractile ring during cell division when used at a concentration of 40 μM but does not affect ring ingression, suggesting that Aurora B kinase activity is not required for that step.

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Binucleine 2 Chemical Structure

Binucleine 2 Chemical Structure

CAS No. : 220088-42-6

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Binucleine 2 Related Antibodies

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Description

Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki=0.36 μM), a kinase involved in cell division. It is specific for Drosophila Aurora B kinase, inhibiting it in a dose-dependent manner, with minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 μM. Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells. It prevents Drosophila S2 cells from assembling a contractile ring during cell division when used at a concentration of 40 μM but does not affect ring ingression, suggesting that Aurora B kinase activity is not required for that step.

IC50 & Target

Aurora B

 

Molecular Weight

291.71

Formula

C13H11ClFN5
CAS No.
SMILES

CN(/C=N/C1=C(C=NN1C2=CC=C(C(Cl)=C2)F)C#N)C
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Purity & Documentation
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Binucleine 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Binucleine 2220088-42-6Binucleine2Binucleine-2Aurora KinaseInhibitorinhibitorinhibit

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