BBMP (Synonyms: 5-(Benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone)

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BBMP is a permeability transition pore (PTP) inhibitor. BBMP prevents Ca²⁺-induced permeability transition and mitochondrial depolarization. BBMP possess potential for the neurodegenerative disorders research.

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BBMP Chemical Structure

CAS No. : 97120-13-3

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Description	BBMP is a permeability transition pore (PTP) inhibitor. BBMP prevents Ca²⁺-induced permeability transition and mitochondrial depolarization. BBMP possess potential for the neurodegenerative disorders research^[1].
In Vitro	BBMP is effective in both swelling and membrane potential assays displaying pIC₅₀ values of 5.5 and 5.6, respectively. BBMP dose-dependently prevents DNA fragmentation induced by KCl 25/5 mM shift and serum deprivation in cerebellar granule neurons with a pIC₅₀ of 5.7. The inhibition of PTP-mediated cytochrome c release observed in isolated mitochondria at 10 and 100 μM may explain its neuroprotective properties in vitro^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. BBMP Related Antibodies
Molecular Weight	343.20
Formula	C₁₂H₁₁BrN₂O₃S
CAS No.	97120-13-3
SMILES	O=C1C(Br)=C(S(=O)(CC2=CC=CC=C2)=O)C=NN1C
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Bruno Fuks, et al. In vitro properties of 5-(benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone: a novel permeability transition pore inhibitor. Eur J Pharmacol. 2005 Sep 5;519(1-2):24-30. [Content Brief]

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BBMP97120-13-35-(Benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinoneMitochondrial Metabolismpermeability transition pore inhibitormitochondrial depolarizationeurodegenerative disordersInhibitorinhibitorinhibit

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BBMP (Synonyms: 5-(Benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone)

BBMP Related Antibodies

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•Related Small Molecules:

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Biological Activity

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