Antalarmin hydrochloride

Cat. No.: HY-103377 Purity: 99.87%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Antalarmin (hydrochloride) is a non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a K_i of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome.

For research use only. We do not sell to patients.

Antalarmin hydrochloride Chemical Structure

CAS No. : 220953-69-5

Size	Price	Stock	Quantity
5 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 610	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Antalarmin hydrochloride:

Antalarmin In-stock

1 Publications Citing Use of MCE Antalarmin hydrochloride

•Immunity. 2024 Feb 13;57(2):364-378.e9. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

415.01

Formula

C₂₄H₃₅ClN₄

CAS No.

220953-69-5

Appearance

Solid

Color

White to light yellow

SMILES

CC1=C(N2C(C)=C(C)C3=C(N(CCCC)CC)N=C(C)N=C32)C(C)=CC(C)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMF : 20 mg/mL (48.19 mM; Need ultrasonic and warming)

Ethanol : 14 mg/mL (33.73 mM; Need ultrasonic and warming)

DMSO : 12.5 mg/mL (30.12 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4096 mL	12.0479 mL	24.0958 mL
5 mM	0.4819 mL	2.4096 mL	4.8192 mL
10 mM	0.2410 mL	1.2048 mL	2.4096 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 15% Cremophor EL 85% Saline
Solubility: 5 mg/mL (12.05 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (253 KB) HNMR (275 KB) RP-HPLC (244 KB) LCMS (259 KB)

Handling Instructions (2659 KB)

References

[1]. Webster EL, et al. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. Endocrinology. 1996 Dec;137(12):5747-50. doi: 10.1210/endo.137.12.8940412. [Content Brief]

[2]. Zorrilla EP, et al. Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Res. 2002 Oct 18;952(2):188-99. [Content Brief]

[3]. Deak T, et al. The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress. Endocrinology. 1999 Jan;140(1):79-86. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / Ethanol / DMF	1 mM	2.4096 mL	12.0479 mL	24.0958 mL	60.2395 mL
	5 mM	0.4819 mL	2.4096 mL	4.8192 mL	12.0479 mL
	10 mM	0.2410 mL	1.2048 mL	2.4096 mL	6.0240 mL
	15 mM	0.1606 mL	0.8032 mL	1.6064 mL	4.0160 mL
	20 mM	0.1205 mL	0.6024 mL	1.2048 mL	3.0120 mL
	25 mM	0.0964 mL	0.4819 mL	0.9638 mL	2.4096 mL
	30 mM	0.0803 mL	0.4016 mL	0.8032 mL	2.0080 mL
DMF	40 mM	0.0602 mL	0.3012 mL	0.6024 mL	1.5060 mL