1. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  2. Reactive Oxygen Species
  3. Allyl methyl trisulfide

Allyl methyl trisulfide is a volatile organic compound and a component of garlic (Allium sativum L.) essential oil, which has antibacterial, antioxidant and antitumor activities.

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Allyl methyl trisulfide Chemical Structure

Allyl methyl trisulfide Chemical Structure

CAS No. : 34135-85-8

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Description

Allyl methyl trisulfide is a volatile organic compound and a component of garlic (Allium sativum L.) essential oil, which has antibacterial, antioxidant and antitumor activities[1].

In Vivo

Allyl methyl trisulfide (AMS) (50-200 mg/kg, orally, daily, 30 days) has protective effect in STZ-induced hyperglycemia rats. It can lead to a significant decrease in the expression of blood glucose and pro-inflammatory markers TNF-α, IL-6, and NF-κB p65, while increasing plasma insulin levels, and has some antioxidant activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (170-190 g)[1]
Dosage: 50, 100 and 200 mg/kg
Administration: orally in the daily morning for 30 days
Result: Enhanced body, organ weight and reduced food, water intake.
Dose-dependently decreased plasma glucose and enhanced insulin.
Attenuated the oxidative stress stimulated by STZ in hepatocytes.
Increased activity of hepatotoxicity markers AST, ALT and ALP.
Significantly downregulated the expression of pro-inflammatory proteins, cytokines (TNF-α and IL-6) and transcription factors (NF-κB p65).
Molecular Weight

152.30

Formula

C4H8S3

CAS No.
SMILES

CSSSCC=C

Initial Source
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Allyl methyl trisulfide
Cat. No.:
HY-134900
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