2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β Beta-secretase
  4. AChE-IN-63

AChE-IN-63 (Compound 5AD) is a selective inhibitor of hAChE (IC50=0.103 μM). AChE-IN-63 also inhibits hBChE and hBACE-1 (IC50= 10 μM (hBChE); 1.342 μM (hBACE-1)). AChE-IN-63 inhibits Aβ aggregation, preventing the formation and deposition of Aβ1-42. AChE-IN-63 can effectively penetrate the blood-brain barrier and is orally effective. It is primarily used in Alzheimer's disease research.

For research use only. We do not sell to patients.

AChE-IN-63 Chemical Structure

AChE-IN-63 Chemical Structure

CAS No. : 876685-78-8

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AChE-IN-63 Related Antibodies

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Description

AChE-IN-63 (Compound 5AD) is a selective inhibitor of hAChE (IC50=0.103 μM). AChE-IN-63 also inhibits hBChE and hBACE-1 (IC50= 10 μM (hBChE); 1.342 μM (hBACE-1)). AChE-IN-63 inhibits Aβ aggregation, preventing the formation and deposition of Aβ1-42. AChE-IN-63 can effectively penetrate the blood-brain barrier and is orally effective. It is primarily used in Alzheimer's disease research[1].

IC50 & Target[1]

hAChE

0.103 μM (IC50)

hBCHE

10 μM (IC50)

In Vitro

AChE-IN-63 (5-20 μM; 48 h) inhibits Aβ1-42 aggregation in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AChE-IN-63 Related Antibodies
In Vivo

AChE-IN-63 (p.o.; 100 mg/kg; single dose) exhibits no toxicity or abnormal reactions in Swiss albino mice[1].
AChE-IN-63 (p.o.; 5-20 mg/kg; single dose) improves learning and memory in cognitive dysfunction mice in the Scopolamine (HY-N0296) Y-Maze Model and demonstrates good antioxidant properties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Scopolamine Y-Maze Model [1]
Dosage: 5; 10 ;20 mg/kg
Administration: p.o.; single dose
Result: Showed significant improvement in spontaneous alternation behavior.
Reduced AChE and MDA levels and increased CAT levels.
Molecular Weight

321.38

Formula

C18H19N5O
CAS No.
SMILES

C1(C2=NN=C(O2)CN3CCN(CC3)C4=CC=CC=N4)=CC=CC=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AChE-IN-63 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-63876685-78-8Cholinesterase (ChE)Amyloid-βBeta-secretaseβ-amyloid peptideAβAbetaBACEβ-SecretaseAlzheimer's DiseaseAnti-Aβ AggregationAntioxidantSwiss Albino MiceY-Maze TestInhibitorinhibitorinhibit

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