2. Signaling Pathways
  3. Immunology/Inflammation
  4. BCL6
  5. BCL6 Inhibitor

BCL6 Inhibitor

BCL6 Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-153521
    CCT374705
    		Inhibitor 99.30%
    CCT374705 is an orally active BCL6 inhibitor with potent antiproliferative effects in vitro. CCT374705 effectively inhibits tumor growth in a lymphoma xenograft mouse model.
  • HY-164098
    JWZ-7-7-Neg1
    		Inhibitor
    JWZ-7-7-Neg1 is a transcriptional chemical inducers of proximity (TCIP) with negative chemical control. JWZ-7-7-Neg1 reduces the ability to bind to BRD4 or BCL6, so it has less cytotoxicity to DLBCL cells, in compared with JWZ-7-7.
  • HY-161138
    WK369
    		Inhibitor
    WK369 is a novel BCL6 small molecule inhibitor, which exhibits excellent anti-ovarian cancer bioactivity, induces cell cycle arrest and causes apoptosis. WK369 can directly bind to the BCL6-BTB domain and block the interaction between BCL6 and SMRT, leading to the reactivation of p53, ATR and CDKN1A.