1. Anti-infection Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  2. Bacterial DNA/RNA Synthesis Endogenous Metabolite
  3. 2-(Methylamino)-1H-purin-6(7H)-one

2-(Methylamino)-1H-purin-6(7H)-one  (Synonyms: N2-methylguanine)

Cat. No.: HY-101412 Purity: ≥98.0%
COA Handling Instructions

2-(Methylamino)-1H-purin-6(7H)-one (N2-Methylguanine) is a modified nucleoside. 2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids.

For research use only. We do not sell to patients.

2-(Methylamino)-1H-purin-6(7H)-one Chemical Structure

2-(Methylamino)-1H-purin-6(7H)-one Chemical Structure

CAS No. : 10030-78-1

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Based on 1 publication(s) in Google Scholar

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Description

2-(Methylamino)-1H-purin-6(7H)-one (N2-Methylguanine) is a modified nucleoside. 2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of 2-(Methylamino)-1H-purin-6(7H)-one substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding[1]. 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E. coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of 2-(Methylamino)-1H-purin-6(7H)-one in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

165.15

Formula

C6H7N5O

CAS No.
Appearance

Solid

Color

Light yellow to khaki

SMILES

O=C1N=C(NC)NC2=C1NC=N2

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

Ethanol : < 1 mg/mL (insoluble)

H2O : < 0.1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
2-(Methylamino)-1H-purin-6(7H)-one
Cat. No.:
HY-101412
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