MethADP (Synonyms: Adenosine 5'-(α,β-methylene)diphosphate)

Cat. No.: HY-112502 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MethADP is a specific CD73 inhibitor.

For research use only. We do not sell to patients.

MethADP Chemical Structure

CAS No. : 3768-14-7

Size	Price	Stock
1 mg	USD 250	Ask For Quote & Lead Time
5 mg	USD 600	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of MethADP:

Other Forms of MethADP:

MethADP triammonium In-stock
MethADP disodium Get quote
MethADP sodium Get quote

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Biological Activity
Purity & Documentation
References
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Description

MethADP is a specific CD73 inhibitor.

IC₅₀ & Target

CD73^[1].

In Vitro

MethADP (AMP-CP: 20 μM) causes a marked inhibition of adenosine formation (0.96±0.96 μM) compared to untreated controls (9.6±1.5 μM) in A498 and RT4 cells, and MethADP (100 μM) completely inhibits the adenosine formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

425.23

Formula

C₁₁H₁₇N₅O₉P₂

CAS No.

3768-14-7

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@H](O)[C@@H](COP(O)(CP(O)(O)=O)=O)O[C@H]1N2C=NC3=C2N=CN=C3N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : ≥ 50 mg/mL (117.58 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3517 mL	11.7583 mL	23.5167 mL
5 mM	0.4703 mL	2.3517 mL	4.7033 mL
10 mM	0.2352 mL	1.1758 mL	2.3517 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (255 KB)

Handling Instructions (2659 KB)

References

[1]. Mohlin C, et al. Studies of the extracellular ATP-adenosine pathway in human urinary tract epithelial cells. Pharmacology. 2009;84(4):196-202. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.3517 mL	11.7583 mL	23.5167 mL	58.7917 mL
	5 mM	0.4703 mL	2.3517 mL	4.7033 mL	11.7583 mL
	10 mM	0.2352 mL	1.1758 mL	2.3517 mL	5.8792 mL
	15 mM	0.1568 mL	0.7839 mL	1.5678 mL	3.9194 mL
	20 mM	0.1176 mL	0.5879 mL	1.1758 mL	2.9396 mL
	25 mM	0.0941 mL	0.4703 mL	0.9407 mL	2.3517 mL
	30 mM	0.0784 mL	0.3919 mL	0.7839 mL	1.9597 mL
	40 mM	0.0588 mL	0.2940 mL	0.5879 mL	1.4698 mL
	50 mM	0.0470 mL	0.2352 mL	0.4703 mL	1.1758 mL
	60 mM	0.0392 mL	0.1960 mL	0.3919 mL	0.9799 mL
	80 mM	0.0294 mL	0.1470 mL	0.2940 mL	0.7349 mL
	100 mM	0.0235 mL	0.1176 mL	0.2352 mL	0.5879 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

MethADP Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MethADP3768-14-7Adenosine 5'-(α,β-methylene)diphosphateCD73ecto-5′-nucleotidase, NT5EInhibitorinhibitorinhibit

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