2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Ivabradine-d6 hydrochloride

Ivabradine-d6 (hydrochloride) is the deuterium labeled Ivabradine hydrochloride. Ivabradine hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent.

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Ivabradine-d<sub>6</sub> hydrochloride Chemical Structure

Ivabradine-d6 hydrochloride Chemical Structure

CAS No. : 2070009-63-9

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5 mg USD 1950 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Ivabradine-d6 (hydrochloride) is the deuterium labeled Ivabradine hydrochloride. Ivabradine hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent.

Molecular Weight

511.08

Formula

C27H31D6ClN2O5
CAS No.
Unlabeled Cas

148849-67-6
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CCCN(C)C[C@@H]2C(C=C(OC)C(OC)=C3)=C3C2)CCC4=CC(OC([2H])([2H])[2H])=C(OC([2H])([2H])[2H])C=C4C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (97.83 mM; Need ultrasonic)

DMSO : 25 mg/mL (48.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9566 mL 9.7832 mL 19.5664 mL
5 mM 0.3913 mL 1.9566 mL 3.9133 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.9566 mL 9.7832 mL 19.5664 mL 48.9160 mL
5 mM 0.3913 mL 1.9566 mL 3.9133 mL 9.7832 mL
10 mM 0.1957 mL 0.9783 mL 1.9566 mL 4.8916 mL
15 mM 0.1304 mL 0.6522 mL 1.3044 mL 3.2611 mL
20 mM 0.0978 mL 0.4892 mL 0.9783 mL 2.4458 mL
25 mM 0.0783 mL 0.3913 mL 0.7827 mL 1.9566 mL
30 mM 0.0652 mL 0.3261 mL 0.6522 mL 1.6305 mL
40 mM 0.0489 mL 0.2446 mL 0.4892 mL 1.2229 mL
H2O 50 mM 0.0391 mL 0.1957 mL 0.3913 mL 0.9783 mL
60 mM 0.0326 mL 0.1631 mL 0.3261 mL 0.8153 mL
80 mM 0.0245 mL 0.1223 mL 0.2446 mL 0.6115 mL
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Ivabradine-d6 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ivabradine-d62070009-63-9Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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