2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. DC1SMe

DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

For research use only. We do not sell to patients.

DC1SMe Chemical Structure

DC1SMe Chemical Structure

CAS No. : 501666-85-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 2634 In-stock
Solid
1 mg USD 795 In-stock
5 mg USD 1750 In-stock
10 mg USD 2795 Get quote
25 mg USD 5312 Get quote
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

DC1SMe Related Antibodies

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Description

DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

IC50 & Target

Duocarmycins

 

Molecular Weight

684.23

Formula

C35H30ClN5O4S2
CAS No.
Unlabeled Cas

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(N1)=CC2=C1C=CC(NC(CCSSC)=O)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Purity & Documentation

Purity: ≥98.0%

COA (248 KB) HNMR (374 KB)

Handling Instructions (2659 KB)
References
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DC1SMe Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DC1SMe501666-85-9ADC CytotoxinADC PayloadInhibitorinhibitorinhibit

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