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AMZ30 is a selective, covalent inhibitors of protein phosphatase methylesterase-1(PME-1; IC50=600 nM); selectively inactivates PME-1 and reduces the demethylated form of PP2A in living cells.

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AMZ30 Chemical Structure

AMZ30 Chemical Structure

CAS No. : 1313613-09-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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 USD 158 En stock
Solution
10 mM * 1 mL in DMSO USD 158 En stock
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5 mg USD 92 En stock
10 mg USD 144 En stock
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Based on 2 publication(s) in Google Scholar

AMZ30 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE AMZ30

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    AMZ30 purchased from MedChemExpress. Usage Cited in: Front Aging Neurosci. 2018 Jun 8;10:173.  [Abstract]

    Immunoblotting and quantifications of deMe-PP2A, total-PP2A, p-α-syn, α-syn, and Flag-LCMT-1 in vector, α-syn, α-syn+LCMT-1, α-syn+AMZ30, α-syn+PP2Ac, and α-syn+siPME-1 group. β-tubulin is used as a loading control.

    • Activité biologique

    • Pureté et documentation

    • Références

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    Description

    AMZ30 is a selective, covalent inhibitors of protein phosphatase methylesterase-1(PME-1; IC50=600 nM); selectively inactivates PME-1 and reduces the demethylated form of PP2A in living cells. IC50 value: 600 nM [1] Target: PME-1 inhibitor in vitro: AMZ30 showed substantially improved inhibition of PME-1 (IC50 value of 600 nM) with more than 100-fold selectivity relative to other SHs in human cell lysates. Incubation of HEK 293T cells with a concentration range of AMZ30 generated an in situ IC50 value for PME-1 inhibition of 3.5 μM as determined by gel-based ABPP without any observed cross-reactivity with other SHs even at 100 μM compound. Treatment of HEK 293T cells stably overexpressing PME-1 with 28 (20 μM) caused an ~80% reduction in the levels of demethylated PP2A [1].

    Masse moléculaire

    461.44

    Formule

    C19H12FN3O6S2
    CAS No.
    Appearance

    Solid

    SMILES

    O=S(C1=CC([N+]([O-])=O)=CC=C1)(N2C(/C=C(S(=O)(C3=CC=C(F)C=C3)=O)\C#N)=CC=C2)=O
    Livraison

    Room temperature in continental US; may vary elsewhere.
    Stockage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvant et solubilité
    In Vitro: 

    DMSO : 100 mg/mL (216.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1671 mL 10.8356 mL 21.6713 mL
    5 mM 0.4334 mL 2.1671 mL 4.3343 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Calculateur de molarité

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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    Working solution concentration: mg/mL
    Pureté et documentation

    Purity: 99.76%

    COA (259 KB) LCMS (94 KB)

    Instruction de manipulation (2659 KB)
    Références

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.1671 mL 10.8356 mL 21.6713 mL 54.1782 mL
    5 mM 0.4334 mL 2.1671 mL 4.3343 mL 10.8356 mL
    10 mM 0.2167 mL 1.0836 mL 2.1671 mL 5.4178 mL
    15 mM 0.1445 mL 0.7224 mL 1.4448 mL 3.6119 mL
    20 mM 0.1084 mL 0.5418 mL 1.0836 mL 2.7089 mL
    25 mM 0.0867 mL 0.4334 mL 0.8669 mL 2.1671 mL
    30 mM 0.0722 mL 0.3612 mL 0.7224 mL 1.8059 mL
    40 mM 0.0542 mL 0.2709 mL 0.5418 mL 1.3545 mL
    50 mM 0.0433 mL 0.2167 mL 0.4334 mL 1.0836 mL
    60 mM 0.0361 mL 0.1806 mL 0.3612 mL 0.9030 mL
    80 mM 0.0271 mL 0.1354 mL 0.2709 mL 0.6772 mL
    100 mM 0.0217 mL 0.1084 mL 0.2167 mL 0.5418 mL
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    AMZ30 Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    AMZ301313613-09-0AMZ 30AMZ-30OthersInhibitorinhibitorinhibit

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