7-Methylguanosine-d₃

Name: 7-Methylguanosine-d 3
Brand: MedChemExpress
SKU: HY-122524S
Rating: 4.5 (1 reviews)

Cat. No.: HY-122524S Purity: 98.54%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

7-Methylguanosine-d3 is the deuterium labeled 7-Methylguanosine[1]. 7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8 ± 7.5 μM[2].

For research use only. We do not sell to patients.

7-Methylguanosine-d<sub>3</sub> Chemical Structure

7-Methylguanosine-d₃ Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 7-Methylguanosine-d₃:

7-Methylguanosine In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

7-Methylguanosine-d3 is the deuterium labeled 7-Methylguanosine[1]. 7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8 ± 7.5 μM[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

301.29

Formula

C₁₁H₁₃D₃N₅O₅

Unlabeled Cas

20244-86-4

Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3[N](C([2H])([2H])[2H])=C2)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H2O : 25 mg/mL (82.98 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3191 mL	16.5953 mL	33.1906 mL
5 mM	0.6638 mL	3.3191 mL	6.6381 mL
10 mM	0.3319 mL	1.6595 mL	3.3191 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.54%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (254 KB) HNMR (450 KB) RP-HPLC (1121 KB) MS (988 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Kozarski M, et al. 7-Methylguanosine monophosphate analogues with 5'-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase. Bioorg Med Chem. 2018 Jan 1;26(1):191-199. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O	1 mM	3.3191 mL	16.5953 mL	33.1906 mL	82.9765 mL
	5 mM	0.6638 mL	3.3191 mL	6.6381 mL	16.5953 mL
	10 mM	0.3319 mL	1.6595 mL	3.3191 mL	8.2977 mL
	15 mM	0.2213 mL	1.1064 mL	2.2127 mL	5.5318 mL
	20 mM	0.1660 mL	0.8298 mL	1.6595 mL	4.1488 mL
	25 mM	0.1328 mL	0.6638 mL	1.3276 mL	3.3191 mL
	30 mM	0.1106 mL	0.5532 mL	1.1064 mL	2.7659 mL
	40 mM	0.0830 mL	0.4149 mL	0.8298 mL	2.0744 mL
	50 mM	0.0664 mL	0.3319 mL	0.6638 mL	1.6595 mL
	60 mM	0.0553 mL	0.2766 mL	0.5532 mL	1.3829 mL
	80 mM	0.0415 mL	0.2074 mL	0.4149 mL	1.0372 mL