7-Benzyloxy-4-(trifluoromethyl)coumarin (Synonyms: 7-BFC)

Cat. No.: HY-W267897 Purity: 98.76%: FAQs
Data Sheet SDS COA Handling Instructions

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7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) is a coumarin fluorescent substrate. 7-Benzyloxy-4-(trifluoromethyl)coumarin is a substrate for cDNA-expressed CYP1A2 and CYP3A4 and is metabolized to 7-hydroxy-4-trifluoromethylcoumarin (HFC). 7-Benzyloxy-4-(trifluoromethyl)coumarin is used for rapid CYP isoform metabolism and inhibition screening studies.

For research use only. We do not sell to patients.

7-Benzyloxy-4-(trifluoromethyl)coumarin Chemical Structure

CAS No. : 220001-53-6

Size	Price	Stock	Quantity
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 165	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Molecular Weight

320.26

Formula

C₁₇H₁₁F₃O₃

CAS No.

220001-53-6

Appearance

Solid

Color

White to off-white

SMILES

C1=CC=C(C=C1)COC2=CC3=C(C=C2)C(=CC(=O)O3)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (390.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1225 mL	15.6123 mL	31.2246 mL
5 mM	0.6245 mL	3.1225 mL	6.2449 mL
10 mM	0.3122 mL	1.5612 mL	3.1225 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.76%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (248 KB) HNMR (255 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. A B Renwick, et al. Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms. Xenobiotica. 2000 Oct;30(10):955-69. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1225 mL	15.6123 mL	31.2246 mL	78.0616 mL
	5 mM	0.6245 mL	3.1225 mL	6.2449 mL	15.6123 mL
	10 mM	0.3122 mL	1.5612 mL	3.1225 mL	7.8062 mL
	15 mM	0.2082 mL	1.0408 mL	2.0816 mL	5.2041 mL
	20 mM	0.1561 mL	0.7806 mL	1.5612 mL	3.9031 mL
	25 mM	0.1249 mL	0.6245 mL	1.2490 mL	3.1225 mL
	30 mM	0.1041 mL	0.5204 mL	1.0408 mL	2.6021 mL
	40 mM	0.0781 mL	0.3903 mL	0.7806 mL	1.9515 mL
	50 mM	0.0624 mL	0.3122 mL	0.6245 mL	1.5612 mL
	60 mM	0.0520 mL	0.2602 mL	0.5204 mL	1.3010 mL
	80 mM	0.0390 mL	0.1952 mL	0.3903 mL	0.9758 mL
	100 mM	0.0312 mL	0.1561 mL	0.3122 mL	0.7806 mL

7-Benzyloxy-4-(trifluoromethyl)coumarin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Benzyloxy-4-(trifluoromethyl)coumarin220001-53-67-BFCCytochrome P450CYPsCoumarinsubstratecDNACYP1A2CYP3A47-hydroxy-4-trifluoromethylcoumarinHFCCYPmetabolisminhibition screeningInhibitorinhibitorinhibit

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7-Benzyloxy-4-(trifluoromethyl)coumarin (Synonyms: 7-BFC)

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7-Benzyloxy-4-(trifluoromethyl)coumarin Related Antibodies

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Complete Stock Solution Preparation Table

7-Benzyloxy-4-(trifluoromethyl)coumarin Related Classifications

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