2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 5-Hydroxymethylcytosine

5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development.

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5-Hydroxymethylcytosine Chemical Structure

5-Hydroxymethylcytosine Chemical Structure

CAS No. : 1123-95-1

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Other Forms of 5-Hydroxymethylcytosine:

5-Hydroxymethylcytosine Related Antibodies

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Description

5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development[1].

Molecular Weight

141.13

Formula

C5H7N3O2
CAS No.
Appearance

Solid

SMILES

O=C1N=CC(CO)=C(N1)N
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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5-Hydroxymethylcytosine Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

5-Hydroxymethylcytosine1123-95-15hmCEndogenous Metabolite5-methylcytosine5mCmammalian5mC oxidasesTen-eleven translocationTET1TET2TET3DNA demethylationgene transcriptionInhibitorinhibitorinhibit

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