Search Result

Results for "

anti-malarial

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Acyltransferase (1) ADC Cytotoxin (1) Akt (3) AMPK (1) Androgen Receptor (1) Antibiotic (23) Antifolate (9) Apoptosis (22) Autophagy (31) Bacterial (30) Bcl-2 Family (4) Calcium Channel (1) CaMK (2) Caspase (5) CDK (3) CMV (1) Cytochrome P450 (5) Dengue virus (4) Dihydrofolate reductase (DHFR) (1) Dihydroorotate Dehydrogenase (5) DNA Methyltransferase (1) DNA Stain (1) DNA/RNA Synthesis (3) Dopamine Receptor (1) Drug Metabolite (8) Endogenous Metabolite (2) Ephrin Receptor (1) Epigenetic Reader Domain (1) ERK (1) FAK (1) Farnesyl Transferase (1) Ferroptosis (7) FKBP (1) Flavivirus (4) Fungal (6) GLUT (2) Glyoxalase (GLO) (1) GSK-3 (2) Guanylate Cyclase (1) HCV (4) HDAC (4) Histamine Receptor (1) Histone Methyltransferase (6) HIV (10) HSP (2) HSV (2) Influenza Virus (6) Isotope-Labeled Compounds (18) Lactate Dehydrogenase (1) MDM-2/p53 (2) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Mitophagy (4) Monoamine Oxidase (1) Na+/K+ ATPase (1) NF-κB (2) NO Synthase (1) Nuclear Hormone Receptor 4A/NR4A (5) Nucleoside Antimetabolite/Analog (1) P-glycoprotein (1) p38 MAPK (6) Parasite (247) PARP (4) PI4K (1) PKA (2) Potassium Channel (8) Proton Pump (2) Reactive Oxygen Species (1) ROS Kinase (2) SARS-CoV (22) Serotonin Transporter (1) Sirtuin (1) Sodium Channel (1) STAT (1) Syk (1) TMV (1) Toll-like Receptor (TLR) (17) Topoisomerase (2) Wnt (2)
By Research Areas:	Cancer (63) Cardiovascular Disease (3) Infection (253) Inflammation/Immunology (43) Metabolic Disease (7) Neurological Disease (19)

By Targets:

5-HT Receptor (1)

Acyltransferase (1)

ADC Cytotoxin (1)

Akt (3)

AMPK (1)

Androgen Receptor (1)

Antibiotic (23)

Antifolate (9)

Apoptosis (22)

Autophagy (31)

Bacterial (30)

Bcl-2 Family (4)

Calcium Channel (1)

CaMK (2)

Caspase (5)

CDK (3)

CMV (1)

Cytochrome P450 (5)

Dengue virus (4)

Dihydrofolate reductase (DHFR) (1)

Dihydroorotate Dehydrogenase (5)

DNA Methyltransferase (1)

DNA Stain (1)

DNA/RNA Synthesis (3)

Dopamine Receptor (1)

Drug Metabolite (8)

Endogenous Metabolite (2)

Ephrin Receptor (1)

Epigenetic Reader Domain (1)

ERK (1)

FAK (1)

Farnesyl Transferase (1)

Ferroptosis (7)

FKBP (1)

Flavivirus (4)

Fungal (6)

GLUT (2)

Glyoxalase (GLO) (1)

GSK-3 (2)

Guanylate Cyclase (1)

HCV (4)

HDAC (4)

Histamine Receptor (1)

Histone Methyltransferase (6)

HIV (10)

HSP (2)

HSV (2)

Influenza Virus (6)

Isotope-Labeled Compounds (18)

Lactate Dehydrogenase (1)

MDM-2/p53 (2)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (1)

Mitophagy (4)

Monoamine Oxidase (1)

Na+/K+ ATPase (1)

NF-κB (2)

NO Synthase (1)

Nuclear Hormone Receptor 4A/NR4A (5)

Nucleoside Antimetabolite/Analog (1)

P-glycoprotein (1)

p38 MAPK (6)

Parasite (247)

PARP (4)

PI4K (1)

PKA (2)

Potassium Channel (8)

Proton Pump (2)

Reactive Oxygen Species (1)

ROS Kinase (2)

SARS-CoV (22)

Serotonin Transporter (1)

Sirtuin (1)

Sodium Channel (1)

STAT (1)

Syk (1)

TMV (1)

Toll-like Receptor (TLR) (17)

Topoisomerase (2)

Wnt (2)

By Research Areas:

Cancer (63)

Cardiovascular Disease (3)

Infection (253)

Inflammation/Immunology (43)

Metabolic Disease (7)

Neurological Disease (19)

276

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114197

Antimalarial agent 14	Mitochondrial Metabolism Parasite	Infection
Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent .

HY-W009109

Antimalarial agent 1

Parasite Infection

Antimalarial agent 1 is a potent antimalarial agent .
HY-W131282

Antimalarial agent 39

Parasite Infection

Antimalarial agent 39 (compound 1) is an intermediate in the synthesis of antimalarial agents .

Antimalarial agent 1	Parasite	Infection
Antimalarial agent 1 is a potent antimalarial agent .

Antimalarial agent 39	Parasite	Infection
Antimalarial agent 39 (compound 1) is an intermediate in the synthesis of antimalarial agents .

HY-149938

Antimalarial agent 25	Parasite	Infection
Antimalarial agent 25 is an orally active 1,4-naphthoquinones derivative with antimalarial activity. Antimalarial agent 25 shows cytotoxicity against P. falciparum. Antimalarial agent 25 inhibits P. burghei induced parasitemia in vivo .

HY-115905

Antimalarial agent 9	Parasite	Infection
Antimalarial agent 9 (Compound 11) is a potent antimalarial agent. Antimalarial agent 9 is a quinoline-imidazole derivative compound. Antimalarial agent 9 exhibits significant antimalarial efficacy in-vitro against both CQ-sensitive (IC₅₀-0.14 μM) and MDR strain (IC₅₀-0.41 μM) with minimal cytotoxicity and high selectivity .

HY-152614

Antimalarial agent 19	Parasite	Infection
Antimalarial agent 19 (compound 6e) is an antimalarial active agent. Antimalarial agent 19 has antimalarial activity for the blood stage of P. falciparum K1 and P. berghei with EC₅₀ values of 0.3 µM, 15.3 µM, respectively. Antimalarial agent 19 has good aqueous solubility, intestinal permeability and microsomal stability compared to gamhepathiopine .

HY-149939

Antimalarial agent 26	Parasite	Infection
Antimalarial agent 26 is an orally active 1,4-naphthoquinones derivative with antimalarial activities. Antimalarial agent 26 shows cytotoxicity against P. falciparum and selectivity over mammalian cell lines. Antimalarial agent 26 inhibits P. burghei induced parasitemia in vivo .

HY-148429

Antimalarial agent 17	Parasite	Others
Antimalarial agent 17 is an antimalarial agent, also acts as a herbicide. Antimalarial agent 17 is photosystem II inhibitor, shows post-emergence herbicidal activity equal to commercial herbicides .

HY-149937

Antimalarial agent 24	Parasite	Infection
Antimalarial agent 24 (Compound 7) is an antimalarial agent in vitro. Antimalarial agent 24 inhibits P. falciparum W2 strain with an IC₅₀ of 0.81 μM. Antimalarial agent 24 displays a CC₅₀ higher than 200 μM against HepG2 cells .

HY-115721

Antimalarial agent 2

Parasite Infection

Antimalarial agent 2 is a novel orally efficacious antimalarials that suggests a fast in vitro killing profile.

Antimalarial agent 2	Parasite	Infection
Antimalarial agent 2 is a novel orally efficacious antimalarials that suggests a fast in vitro killing profile.

HY-161170

Antimalarial agent 36	Parasite	Infection
Antimalarial agent 36 (compound 1) is an antimalarial agent, with the EC₅₀s of 58 nM and 42 nM, for Dd2 and 3D7, respectively. Antimalarial agent 36 targets EphA2 .

HY-149919

Antimalarial agent 23	Parasite	Infection
Antimalarial agent 23 is an *antimalarial* benzimidazole with IC₅₀s of 0.08 μM and 0.10 μM for PfNF54 and PfK1, respectively. Antimalarial agent 23 has potent β-hematin inhibition activity. Antimalarial agent 23 does not directly inhibit the conversion of heme to hemozoin .

HY-150066

Antimalarial agent 16	Parasite	Infection Inflammation/Immunology
Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC₅₀=2.0 nM) .

HY-163070

Antimalarial agent 35	Others	Infection
Antimalarial agent 35 (compound QP11) is a selective inhibitor FP2. Antimalarial agent 35 has antimalarial activity and shows synergistic effects when combined with chloroquine(HY-17589A) .

HY-147198

Antimalarial agent 13	Parasite	Infection
Antimalarial agent 13 (Compound 1) is a potent *antimalarial* agent. Antimalarial agent 13 shows inhibition with EC₅₀ values of 124 nM and 2.5 μM against P. falciparum parasite and HepG2, respectively .

HY-145704

Antimalarial agent 8	Parasite	Infection
Antimalarial agent 8 (Compound 7e) is a novel orally active class of antimalarials. Antimalarial agent 8 is potent in vitro against P. falciparum and is orally efficacious (40 mg/kg) in an in vivo mouse model of malaria .

HY-150065

Antimalarial agent 15	Parasite	Infection Inflammation/Immunology
Antimalarial agent 15 (Compound 4e) is a parasite inhibitor. Antimalarial agent 15 shows antimalarial activity, and can inhibit P. falciparum 3D7 parasite growth (IC₅₀=20 nM) .

HY-151965

Antimalarial agent 18	Parasite	Infection
Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibits P. falciparum (IC₅₀=50 nM) and A. baumanii (IC₅₀=390 nM) .

HY-143487

Antimalarial agent 12	Parasite	Infection
Antimalarial agent 12 (compound R-3b) is a potent *antimalarial* agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC₅₀=155 nM), 3D7 strain (EC₅₀=136 nM). Antimalarial agent 12 has CC₅₀ values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. Antimalarial agent 12 has a MIC of >250,000 nM for Escherichia coli .

HY-146769

Antimalarial agent 11	Parasite	Infection
Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent *antimalarial* agent. Antimalarial agent 11 exhibits excellent potency with an EC₅₀ of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC₅₀s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively .

HY-155689

Antimalarial agent 30

Parasite Infection

Antimalarial agent 30 (compound 11) is an antimalarial agent that inhibits P. berghei liver stage parasite load with an EC₅₀ of 5.2 μM .
HY-155688

Antimalarial agent 29

Parasite Infection

Antimalarial agent 29 (compound 16) is an antimalarial agent that inhibits P. berghei liver stage parasite load with an EC₅₀ of 5.2 μM .

Antimalarial agent 30	Parasite	Infection
Antimalarial agent 30 (compound 11) is an antimalarial agent that inhibits P. berghei liver stage parasite load with an EC₅₀ of 5.2 μM .

Antimalarial agent 29	Parasite	Infection
Antimalarial agent 29 (compound 16) is an antimalarial agent that inhibits P. berghei liver stage parasite load with an EC₅₀ of 5.2 μM .

HY-143409

Antimalarial agent 10	Parasite	Infection
Antimalarial agent 10 (Compound 17b) is an aminoalcohol quinoline compound. Antimalarial agent 10 is an antimalarial agent with IC₅₀ values of 14.9 nM and 11.0 nM against respectively Pf3D7 and PfW2 and a selectivity index higher than 770 whatever the cell line is .

HY-123915

Antimalarial agent 20	Parasite	Infection
Antimalarial agent 20 (Compound 49c) is an antimalarial agent with an IC₅₀ of 0.6 nM against P. falciparum NF54 parasite strain in the NF54 albumax assay .

HY-149882

Antimalarial agent 27	Parasite	Infection
Antimalarial agent 27 (compound 11a) is an antimalarial agent, potently targeting to P.falciparum (IC₅₀=0.37 μM). Antimalarial agent 27 acts function via P.falciparum DXR (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibition (IC₅₀=0.11 μM) .

HY-145327

Antimalarial agent 7	Na+/K+ ATPase Parasite	Infection
Antimalarial agent 7 is a potent inhibitor of PfATP4. PfATP4 is an essential ion pump on the parasite surface. Antimalarial agent 7 has the potential for the research of human malaria parasite, Plasmodium falciparum .

HY-155354

Antimalarial agent 33	Parasite	Infection
Antimalarial agent 33 (compound 5g) has antiplasmodial activity against erythrocytic and hepatic stages of Plasmodium with an EC₅₀ of 1.1 μM for K1 P. falciparum strain. Antimalarial agent 33 demonstrats enhanced microsomal stability (T_1/2=29 min). Antimalarial agent 33 has no significant cytotoxicity against primary hepatocytes .

HY-161171

Antimalarial agent 37	Parasite Ephrin Receptor	Cancer
Antimalarial agent 37 (compound 33) is a selective inhibitor against Type Ⅱ kinase with antiplasmodial activity. Antimalarial agent 37 exhibited cytotoxicity and selectivity towards cancer cells HepG2 and MCF 7 .

HY-155536

Antimalarial agent 28	Parasite	Infection
Antimalarial agent 28 (Compound 2i) is an antiplasmodial agent. Antimalarial agent 28 inhibits P. berghei, with IC₅₀s of 0.561 μM, 0.14 μM, 4.34 μM for Liver stage, early gametocytes and ring stages of P. falciparum .

HY-157892

Antimalarial agent 38	Parasite	Infection
Antimalarial agent 38 (Compound 1) exhibits activity against antiplasmodial, which inhibits Plasmodium falciparum D6 strain, chloroquine-sensitive Thai strain and chloroquine-resistant FcB1 strain and K1 strain, with IC₅₀s of 0.5, 13, 1 and 13 μM, respectively. Antimalarial agent 38 is non-cytotoxic for mammalian cells MCR58 (IC₅₀ >140 μM). Antimalarial agent 38 improves the survival rate of Plasmodium yoelii nigeriensis infected mouse model .

HY-155130

Antimalarial agent 31

Parasite Infection

Antimalarial agent 31 (compound 7k) is an orally active Plasmodium falciparum aspartic protease plasmepsin X (PMX) inhibitor .
HY-163063

Antimalarial agent 34

Parasite Infection

Antimalarial agent 34 is a modest PfARK1/3 inhibitor and shows potent antiplasmodial activity (EC₅₀ = 0.16 μM) .

Antimalarial agent 31	Parasite	Infection
Antimalarial agent 31 (compound 7k) is an orally active Plasmodium falciparum aspartic protease plasmepsin X (PMX) inhibitor .

Antimalarial agent 34	Parasite	Infection
Antimalarial agent 34 is a modest PfARK1/3 inhibitor and shows potent antiplasmodial activity (EC₅₀ = 0.16 μM) .

HY-132906

Antimalarial agent 3	Parasite	Infection
Antimalarial agent 3 shows nanomolar antiplasmodial activity (IC₅₀ = 0.035 μM) and has a very high selectivity index with respect to mammalian cells.

HY-N2899

Arteannuin M

Parasite Infection

Arteannuin M can be isolated from Artemisia annua, and can be used for anti-malarial research .
HY-N2900

Arteannuin N

Parasite Infection

Arteannuin N can be isolated from Artemisia annua, and can be used for anti-malarial research .

Arteannuin M	Parasite	Infection
Arteannuin M can be isolated from Artemisia annua, and can be used for anti-malarial research .

Arteannuin N	Parasite	Infection
Arteannuin N can be isolated from Artemisia annua, and can be used for anti-malarial research .

HY-N2903

Artoheterophyllin B	Parasite	Infection
Artoheterophyllin B can be isolated from A. heterophyllus. Artoheterophyllin B shows antiplasmodial activity (IC₅₀: 13.7 μM against FcB1 strain). Artoheterophyllin B can be used for anti-malarial research .

HY-16762

Artefenomel 2 Publications Verification OZ439	Parasite Ferroptosis SARS-CoV	Infection
Artefenomel (OZ439) is an orally active, synthetic anti-malarial compound containing an artemisinin pharmacophore with a mechanism of action similar to that of artemisinin. Artefenomel has antiviral activity against SARS-CoV-2 .

HY-B0433A

Quinine hydrochloride dihydrate 2 Publications Verification	Flavivirus Dengue virus Parasite Potassium Channel	Infection
Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-D0143A

Quinine dihydrochloride	Flavivirus Dengue virus Parasite Potassium Channel	Infection
Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-B0433B

Quinine hemisulfate	Flavivirus Dengue virus Parasite Potassium Channel	Infection
Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-W010668

Quinine sulfate hydrate 2 Publications Verification	Flavivirus Dengue virus Parasite Potassium Channel	Others
Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-13557

Ascomycin 5+ Cited Publications Immunomycin; FR-900520; FK520	FKBP Parasite Fungal Antibiotic	Infection Neurological Disease Inflammation/Immunology
Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .

HY-N0402

Artemether Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224	Parasite	Infection Inflammation/Immunology Cancer
Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .

HY-111529

Tafenoquine

WR 238605
Parasite Infection

Tafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent .

Tafenoquine WR 238605	Parasite	Infection
Tafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent .

HY-N7030

5,7,3',4'-Tetramethoxyflavone	Fungal Parasite Bacterial	Infection
5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling .

HY-111529A

Tafenoquine Succinate 4 Publications Verification WR 238605 (Succinate)	Parasite	Infection
Tafenoquine Succinate (WR 238605 Succinate) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent .

HY-B0803S1

Lumefantrine-d9 Benflumetol-d₉	Isotope-Labeled Compounds Parasite Autophagy	Infection
Lumefantrine-d₉ is the deuterium labeled Lumefantrine. Lumefantrine is an antimalarial drug, used in combination with Artemether. The artemether-lumefantrine (AL) as the first- and second-line anti-malarial drugs.

HY-147850

JMI-346	Parasite	Infection
JMI-346 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-346 inhibits the growth of CQ ^S (3D7; IC₅₀=13 µM) and CQ ^R (RKL-9; IC₅₀=33 µM) strains of P. falciparum. JMI-346 has the potential to be used as an anti-malarial agent .

HY-14749

Pyronaridine	Parasite	Infection
Pyronaridine is an orally active Mannich base anti-malarial agent. Pyronaridine is active against P. falciparum and Echinococcus granulosus infection .

HY-14749A

Pyronaridine tetraphosphate 2 Publications Verification	Parasite	Infection
Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0433A

Quinine hydrochloride dihydrate 2 Publications Verification	Infection Alkaloids Structural Classification Classification of Application Fields Source classification Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields	Flavivirus Dengue virus Parasite Potassium Channel
Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-N2899

Arteannuin M	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Artemisia annua L. Compositae	Parasite
Arteannuin M can be isolated from Artemisia annua, and can be used for anti-malarial research .

HY-N2900

Arteannuin N	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Artemisia annua L. Compositae	Parasite
Arteannuin N can be isolated from Artemisia annua, and can be used for anti-malarial research .

HY-N2903

Artoheterophyllin B	Structural Classification Source classification Phenols Polyphenols Plants Moraceae	Parasite
Artoheterophyllin B can be isolated from A. heterophyllus. Artoheterophyllin B shows antiplasmodial activity (IC₅₀: 13.7 μM against FcB1 strain). Artoheterophyllin B can be used for anti-malarial research .

HY-D0143A

Quinine dihydrochloride	Cinchona succirubra Pav. ex Klotzsch Natural Products Source classification Rubiaceae Plants	Flavivirus Dengue virus Parasite Potassium Channel
Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-B0433B

Quinine hemisulfate	Cinchona succirubra Pav. ex Klotzsch Source classification Rubiaceae Quinoline Alkaloids Plants	Flavivirus Dengue virus Parasite Potassium Channel
Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-W010668

Quinine sulfate hydrate 2 Publications Verification	Source classification Plants	Flavivirus Dengue virus Parasite Potassium Channel
Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM .

HY-13557

Ascomycin 5+ Cited Publications Immunomycin; FR-900520; FK520	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Antifungal Macrolide Antibiotics Neurological Disease Classification of Application Fields Antibiotics Source classification Disease Research Inflammation/Immunology Disease Research Fields	FKBP Parasite Fungal Antibiotic
Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .

HY-N0402

Artemether Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Cancer	Parasite
Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .

HY-N7030

5,7,3',4'-Tetramethoxyflavone	Infection Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Rutaceae Plants Disease Research Fields Murraya exotica L. Mant.	Fungal Parasite Bacterial
5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling .

HY-N2281

Leachianone A	Structural Classification Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Sophora flavescens Aiton Plants Inflammation/Immunology Disease Research Fields	Apoptosis
Leachianone A, isolated from Radix Sophorae, has anti-malarial, anti-inflammatory, and cytotoxic potent . Leachianone A induces apoptosis involved both extrinsic and intrinsic pathways .

HY-10529

Betulinic acid Maximum Cited Publications 23 Publications Verification Lupatic acid; Betulic acid	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties .

HY-N12077

Eurycomanol 2-O-β-D-glucopyranoside	Structural Classification Simaroubaceae Source classification Plants Saccharides Monosaccharides	Parasite
Eurycomanol 2-O-β-D-glucopyranoside (compound 4) is a natural product that can be obtained from Eurycoma longifolia. Eurycomanol 2-O-β-D-glucopyranoside has the potential for anti-malarial research .

HY-107566

Conessine	Infection Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids	Histamine Receptor Parasite
Conessine, a steroidal alkaloid, is a potent and selective histamine H₃ receptor antagonist with K_is of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H₃ receptor, respectively. Anti-malarial activity .

HY-B0094

Artemisinin 10+ Cited Publications Qinghaosu; NSC 369397	Infection Structural Classification Piscidia erythrina L. Neurological Disease Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields	HCV Parasite Akt Ferroptosis
Artemisinin (Qinghaosu), a sesquiterpene lactone, is an *anti-malarial* agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .

HY-N1074

Warangalone Scandenolone	Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones Erythrina variegata Linn.	Parasite PKA
Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC₅₀s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC₅₀ of 3.5 μM.

HY-N1457

Chrysosplenetin	Flavonols Structural Classification Piscidia erythrina L. Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Compositae Disease Research Fields	P-glycoprotein Cytochrome P450 Ferroptosis
Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A .

HY-N0674A

Dehydrocorydaline chloride Maximum Cited Publications 23 Publications Verification 13-Methylpalmatine chloride	Infection Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0674

Dehydrocorydaline Maximum Cited Publications 23 Publications Verification 13-Methylpalmatine	Infection Alkaloids Structural Classification Classification of Application Fields Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0498

Nitidine chloride 2 Publications Verification	Alkaloids Classification of Application Fields Source classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
Nitidine chloride, a potential *anti-malarial* lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-N0674B

Dehydrocorydaline (hydroxyl) 20+ Cited Publications 13-Methylpalmatine (hydroxyl)	Structural Classification Alkaloids Corydalis yanhusuo W. T. Wang Source classification Plants Papaveraceae	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

HY-N4238

Dehydrocorydaline nitrate 20+ Cited Publications 13-Methylpalmatine nitrate	Infection Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. . Dehydrocorydaline nitrate shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N3957

1-(26-Hydroxyhexacosanoyl)-glycerol	Structural Classification Natural Products Source classification Rourea minor (Gaerth.) Leenh. Plants Connaraceae	Parasite
1-(26-Hydroxyhexacosanoyl)-glycerol is a potent antimalarial agent. 1-(26-Hydroxyhexacosanoyl)-glycerol shows antimalarial activity with an IC₅₀ value of 9.48 µM for Plasmodium falciparum .

HY-118494

Ascaridole	Structural Classification Natural Products Source classification Plants Dysphania ambrosioides (Linnaeus) Mosyakin & Clemants Chenopodiaceae	Parasite
Ascaridole is an anthelmintic and also has antimalarial activity .

HY-N4106

Dihydroartemisinic acid Dihydroqinghao acid	Infection other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Disease Research Fields	Parasite Ferroptosis
Dihydroartemisinic acid (Dihydroqinghao acid) is a biosynthetic precursor to the antimalarial agent Artemisinin .

HY-N2384

Febrifugine	Infection Alkaloids Structural Classification Classification of Application Fields Dichroa febrifuga Lour Source classification Pyridine Alkaloids Plants Saxifragaceae Disease Research Fields	Parasite
Febrifugine is a quinazolinone alkaloid found in the roots and leaves of Dichroa febrifuga, with antimalarial activity .

HY-N2384A

Febrifugine dihydrochloride	Infection Alkaloids Structural Classification Classification of Application Fields Dichroa febrifuga Lour Source classification Pyridine Alkaloids Plants Saxifragaceae Disease Research Fields	Parasite
Febrifugine dihydrochloride is a quinazolinone alkaloid found in the roots and leaves of Dichroa febrifuga, with antimalarial activity .

HY-N0352

Tuberostemonine	Infection Alkaloids other families Pyrrole Alkaloids Classification of Application Fields Source classification Plants Disease Research Fields	Parasite
Tuberostemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP ⁺ reductases (pfFNR) .

HY-N12276

(±)-Emodin bianthrone	Structural Classification Microorganisms Source classification Phenols Polyphenols	Parasite Bacterial Fungal
(±)-Emodin bianthrone (compound 10), a natural product, exhibits antimalarial, antitubercular and ntifungal activities .

HY-N5029

Isofebrifugine	Infection Alkaloids Classification of Application Fields Dichroa febrifuga Lour Source classification Quinoline Alkaloids Plants Saxifragaceae Disease Research Fields	Parasite
Isofebrifugine is a natural quinazolinone alkaloid with important physiological activities and good pharmacological effects. Antimalarial effect .

HY-N1075

Walsuronoid B	Triterpenes Structural Classification Terpenoids Source classification Plants Meliaceae Walsura robusta Roxb.	Parasite
Walsuronoid B is a limonoid can be isolated from Walsura robusta and has weak antimalarial activity .

HY-W007771

Acridone	Infection Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields	Bacterial
Acridone is an organic compound based on the acridine skeleton. Acridone has antibacterial, antimalarial, antiviral and anti neoplastic activities .

HY-121002

Alstonine	Infection Apocynaceae Alkaloids Structural Classification Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Alstonia scholaris (L.) R. Br. Plants Disease Research Fields Indole Alkaloids	Parasite
Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties .

HY-N0176A

α-Dihydroartemisinin α-Dihydroqinghaosu; α-Artenimol	Structural Classification Terpenoids Sesquiterpenes Source classification Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae	Parasite
α-Dihydroartemisinin is a natural product that can be found in artemisinin. α-Dihydroartemisinin also shows antimalarial activity .

HY-124301

Penicolinate A	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Pyridine Alkaloids Disease Research Fields	Bacterial
Penicolinate A is a picolinic acid derivative. Penicolinate A is isolated from endophytic Penicillium sp. BCC16054. Penicolinate A exhibits antimalarial and antitubercular activities .

HY-N7190

Yadanzioside F	Structural Classification Simaroubaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.	Parasite
Yadanzioside F is one of the toxic components found in Brucea javanica . Brucea javanica has demonstrated a variety of antitumoral, antimalarial, and anti-inflammatory properties .

HY-N9438

Lactucin	Iridoids Genista quadriflora Munby Source classification Plants Compositae	Apoptosis Parasite
Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities .

HY-N7634

Tectol	Infection Structural Classification other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	Farnesyl Transferase Parasite
Tectol, isolated from Lippia sidoides, exhibits significant activity against human leukemia cell lines HL60 and CEM . Tectol is a farnesyltransferase (FTase) inhibitor with IC₅₀s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC₅₀ of 3.44 μM .

HY-N7314

Asebogenin	Structural Classification Populus balsamifera L. Source classification Phenols Polyphenols Plants Salicaceae	Syk
Asebogenin has antimalarial activity in vitro . Asebogenin can inhibit the phosphorylation of Syk, thereby effectively suppressing platelet activation and the formation of neutrophil extracellular traps .

HY-N0941

beta-Mangostin 1 Publications Verification β-Mangostin	Infection Xanthones Classification of Application Fields Source classification Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Plants Disease Research Fields Cancer	Bacterial Parasite Apoptosis
beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC₅₀ of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) .

HY-N2753

7-Acetoxybonducellpin C	Structural Classification Leguminosae Caesalpinia crista L. Terpenoids Source classification Diterpenoids Plants	Parasite
7-Acetoxybonducellpin C, a diterpenoid, is a nature product that could be isolated from the seed kernels of Caesalpinia crista. 7-Acetoxybonducellpin C has antimalarial activity .

HY-N7281

Aphadilactone C	Structural Classification Terpenoids Source classification Diterpenoids Plants Meliaceae Aphanamixis polystachya (Wall.) R. N. Parker	Acyltransferase Parasite
Aphadilactone C is a potent and selective DGAT-1 inhibitor with an IC₅₀ of 0.46 μM. Aphadilactone C shows significant antimalarial activities with an IC₅₀ value of 170 nM .

HY-N8338

Pancixanthone A	Structural Classification Flavonoids Source classification Guttiferae Garcinia vieillardii Pierre Plants Other Flavonoids	Parasite
Pancixanthone A is a xanthone that can be isolated from Garcinia vieillardii. Pancixanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 1.6 μg/mL .

HY-N8455

Isocudraniaxanthone A Assiguxanthone A	Structural Classification Flavonoids Xanthones Calophyllum caledonicum Vieill. ex Planch. & Triana Source classification Phenols Plants Calophyllaceae Other Flavonoids	Parasite
Isocudraniaxanthone A is a xanthone that can be isolated from Garcinia vieillardii. Isocudraniaxanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 2.3 μg/mL .

HY-N12700

Puberulic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Parasite
Puberulic acid has *antimalarial* activity against Plasmodium falciparum K1 (chloroquine-resistant), IC₅₀ value is 0.050 µM. Puberulic acid can be isolated from Penicillium viticola .

HY-N0978

1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid	Infection Agrimonia pilosa Ledeb. Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Rosaceae Metabolic Disease Plants Disease Research Fields	Parasite
1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid is a Triterpenoid that isolated from the plant of Agrimonia Pilosa with antimalarial and antidiabetic activities .

HY-N2759

7-O-Isopentenyl-γ-fagarine	Structural Classification Alkaloids Peltostigma guatemalense (Standl. & Steyerm.) Gereau Source classification Rutaceae Quinoline Alkaloids Plants	Bacterial
7-O-Isopentenyl-γ-fagarine is an alkaloid that can be isolated from Peltostigma guatemalense. 7-O-Isopentenyl-γ-fagarine has antibacterial and antimalarial activities in vitro .

HY-N8345

Isocudraniaxanthone B	Guttiferae Garcinia vieillardii Pierre Source classification Plants	Others
Isocudraniaxanthone B (compound 10) is a kind of xanthone. Isocudraniaxanthone B can be isolated from Calophyllum caledonicum. Isocudraniaxanthone B has *antimalarial* activity with an IC50 value of 3.2 μg/mL .

HY-N7512

Asimilobine	Infection Alkaloids Monophenols Classification of Application Fields Source classification Phenols Nelumbo nucifera Gaertn. Plants Isoquinoline Alkaloids Disease Research Fields Nymphaeaceae	Dopamine Receptor 5-HT Receptor Parasite
Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an *antimalarial* and anti-cancer activity .

HY-N10368

Shinjulactone M	Infection Simaroubaceae Ailanthus altissima (Mill.) Swingle Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Inflammation/Immunology Disease Research Fields	Parasite
Shinjulactone M is a quassinoid isolated from various parts of Ailanthus species. Ailanthus, an important genus of the Simaroubaceae family, can be used as an febrifuge (antimalarial) and anthelmintic, and is given for the research of chronic bronchitis, epilepsy and asthma .

Cat. No.	Product Name	Chemical Structure

HY-B0803S1

Lumefantrine-d9
Lumefantrine-d₉ is the deuterium labeled Lumefantrine. Lumefantrine is an antimalarial drug, used in combination with Artemether. The artemether-lumefantrine (AL) as the first- and second-line anti-malarial drugs.

HY-14749AS

Pyronaridine-d4 tetraphosphate
Pyronaridine-d₄ (tetraphosphate) is the deuterium labeled Pyronaridine tetraphosphate[1]. Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[2][3].

HY-B0094S

Artemisinin-d3

Artemisinin-d₃ is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].

HY-B0094S3

Artemisinin-13C,d4

Artemisinin- ¹³C,d₄ is ¹³C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .

HY-B1896S

Piperaquine-d6
Piperaquine-d₆ is the deuterium labeled Piperaquine[1]. Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[2][3].

HY-118865S

Piperaquine-d6 tetraphosphate
Piperaquine-d₆ (tetraphosphate) is the deuterium labeled Piperaquine tetraphosphate. Piperaquine tetraphosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin[1][2].

HY-B0803S

Lumefantrine-d18

Lumefantrine-d₁₈ is the deuterium labeled Lumefantrine, which is an antimalarial agent.
HY-B0806S

Proguanil-d6

Proguanil-d₆ is the deuterium labeled Proguanil, which is a prophylactic antimalarial agent.
HY-N0402S

Artemether-d3

Artemether-d₃ is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.
HY-B0273S1

Sulfadiazine-13C6

Sulfadiazine- ¹³C₆ is a labeled Sulfadiazine (HY-B0273). Sulfadiazine is a sulfonamide?antibiotic with antimalarial activity[1].
HY-A0130S

Sulfalene-13C6

Sulfalene- ¹³C₆ is the ¹³C₆ labeled Sulfalene. Sulfalene (Sulfametopyrazine) is an antimalarial agent. Sulfalene is also a long-acting sulfonamide antibacterial .

HY-B0806AS

Proguanil-d4 hydrochloride
Proguanil-d₄ (hydrochloride) is the deuterium labeled Proguanil hydrochloride. Proguanil hydrochloride, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor[1][2].

HY-100662S

Didesethyl chloroquine-d4
Didesethyl chloroquine-d₄ is the deuterium labeled Didesethyl chloroquine. Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant[1][2].

HY-B0806S1

Proguanil-d4
Proguanil-d₄ is the deuterium labeled Proguanil[1]. Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor[2][3].

HY-B0806AS1

Proguanil-d6 hydrochloride
Proguanil-d₆ hydrochloride is the deuterium labeled Proguanil hydrochloride (HY-B0806A). Proguanil hydrochloride, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor .

HY-W031727S

Hydroxychloroquine-d4-1 sulfate
Hydroxychloroquine-d₄-1 (sulfate) is the deuterium labeled Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

HY-W031727S1

Hydroxychloroquine-d5
Hydroxychloroquine-d₅ is the deuterium labeled Hydroxychloroquine[1]. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[2][3][4].

HY-B1370S

Hydroxychloroquine-d4 sulfate
Hydroxychloroquine-d₄ (sulfate) is the deuterium labeled Hydroxychloroquine sulfate. Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

HY-B1322AS

Amodiaquine-d10
Amodiaquine-d₁₀ is the deuterium labeled Amodiaquine. Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4].

HY-17589AS

Chloroquine-d5 1 Publications Verification
Chloroquine-d₅ is deuterium labeled Chloroquine. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-17589S1

Chloroquine-d4 phosphate

Chloroquine-d₄ (phosphate) is the deuterium labeled Chloroquine phosphate. Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-17589S

Chloroquine-d5 diphosphate

Chloroquine-d₅ (diphosphate) is the deuterium labeled Chloroquine (phosphate). Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

HY-B1322AS1

Amodiaquine-d10 hydrochloride
Amodiaquine-d₁₀ hydrochloride is deuterated labeled Amodiaquine (HY-B1322A). Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC₅₀ of ~20 μM. Anti-inflammatory effect .

HY-135810S

Cletoquine-d4

Cletoquine-d₄ is deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

HY-13832S2

Atovaquone-d5

Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-135810S1

Cletoquine-d4-1

Cletoquine-d₄-1 is the deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

HY-13832S3

cis-Atovaquone-d4

cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks