2. Anti-infection Autophagy Immunology/Inflammation
  3. Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV
  4. Chloroquine-d5

Chloroquine-d5 is deuterium labeled Chloroquine. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

For research use only. We do not sell to patients.

Chloroquine-d<sub>5</sub> Chemical Structure

Chloroquine-d5 Chemical Structure

CAS No. : 1854126-41-2

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5 mg USD 970 Get quote
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Based on 1 publication(s) in Google Scholar

Other Forms of Chloroquine-d5:

Chloroquine-d5 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Chloroquine-d5

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  • Biological Activity

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Description

Chloroquine-d5 is deuterium labeled Chloroquine. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].

IC50 & Target[1][2][3][5]

Plasmodium

 

Malaria

 

TLRs

 

SARS-COV-2

 

HIV-1

 

Molecular Weight

324.90

Formula

C18H21D5ClN3
CAS No.
Unlabeled CAS

54-05-7
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCN(CC)C([2H])([2H])C([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (153.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0779 mL 15.3894 mL 30.7787 mL
5 mM 0.6156 mL 3.0779 mL 6.1557 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 100.00%

COA (245 KB) LCMS (179 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0779 mL 15.3894 mL 30.7787 mL 76.9468 mL
5 mM 0.6156 mL 3.0779 mL 6.1557 mL 15.3894 mL
10 mM 0.3078 mL 1.5389 mL 3.0779 mL 7.6947 mL
15 mM 0.2052 mL 1.0260 mL 2.0519 mL 5.1298 mL
20 mM 0.1539 mL 0.7695 mL 1.5389 mL 3.8473 mL
25 mM 0.1231 mL 0.6156 mL 1.2311 mL 3.0779 mL
30 mM 0.1026 mL 0.5130 mL 1.0260 mL 2.5649 mL
40 mM 0.0769 mL 0.3847 mL 0.7695 mL 1.9237 mL
50 mM 0.0616 mL 0.3078 mL 0.6156 mL 1.5389 mL
60 mM 0.0513 mL 0.2565 mL 0.5130 mL 1.2824 mL
80 mM 0.0385 mL 0.1924 mL 0.3847 mL 0.9618 mL
100 mM 0.0308 mL 0.1539 mL 0.3078 mL 0.7695 mL
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Chloroquine-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chloroquine-d51854126-41-2ParasiteAutophagySARS-CoVToll-like Receptor (TLR)HIVSARS coronavirusHuman immunodeficiency virusChloroquinedeuteriumlabeledanti-inflammatoryantimalarialCOVID-19Inhibitorinhibitorinhibit

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