Amodiaquine-d₁₀

Name: Amodiaquine-d 10
Brand: MedChemExpress
SKU: HY-B1322AS
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1322AS Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Amodiaquine-d₁₀ is the deuterium labeled Amodiaquine. Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4].

For research use only. We do not sell to patients.

Amodiaquine-d<sub>10</sub> Chemical Structure

Amodiaquine-d₁₀ Chemical Structure

CAS No. : 1189449-70-4

Size	Price	Stock	Quantity
1 mg	USD 900	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 2700	Get quote	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Amodiaquine-d₁₀:

Amodiaquine In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Plasmodium

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

365.92

Formula

C₂₀H₁₂D₁₀ClN₃O

CAS No.

1189449-70-4

Unlabeled CAS

86-42-0

Appearance

Solid

Color

White to off-white

SMILES

ClC(C=C1)=CC2=C1C(NC3=CC(CN(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])=C(C=C3)O)=CC=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 66.67 mg/mL (182.20 mM; ultrasonic and adjust pH to 3 with 1M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7328 mL	13.6642 mL	27.3284 mL
5 mM	0.5466 mL	2.7328 mL	5.4657 mL
10 mM	0.2733 mL	1.3664 mL	2.7328 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (251 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Chun-Hyung Kim, et al. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61. [Content Brief]

[3]. Keita Kinoshita, et al. A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage. J Neuroimmunol. 2019 May 15;330:48-54. [Content Brief]

[4]. Akira Yokoyama, et al. Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84. [Content Brief]

[5]. M T HOEKENGA. The treatment of acute malaria with single oral doses of amodiaquin, chloroquine, hydroxychloroquine and pyrimethamine. Am J Trop Med Hyg. 1954 Sep;3(5):833-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7328 mL	13.6642 mL	27.3284 mL	68.3209 mL
	5 mM	0.5466 mL	2.7328 mL	5.4657 mL	13.6642 mL
	10 mM	0.2733 mL	1.3664 mL	2.7328 mL	6.8321 mL
	15 mM	0.1822 mL	0.9109 mL	1.8219 mL	4.5547 mL
	20 mM	0.1366 mL	0.6832 mL	1.3664 mL	3.4160 mL
	25 mM	0.1093 mL	0.5466 mL	1.0931 mL	2.7328 mL
	30 mM	0.0911 mL	0.4555 mL	0.9109 mL	2.2774 mL
	40 mM	0.0683 mL	0.3416 mL	0.6832 mL	1.7080 mL
	50 mM	0.0547 mL	0.2733 mL	0.5466 mL	1.3664 mL
	60 mM	0.0455 mL	0.2277 mL	0.4555 mL	1.1387 mL
	80 mM	0.0342 mL	0.1708 mL	0.3416 mL	0.8540 mL
	100 mM	0.0273 mL	0.1366 mL	0.2733 mL	0.6832 mL